Abstract microRNAs (miRNAs) are small regulatory RNAs that are important in development
and disease,, and therefore represent a potential new class of targets for therapeutic …

MicroRNAs (miRNAs) are an abundant class of non-coding RNAs that are believed to be
important in many biological processes through regulation of gene expression,,. The precise …

Systemic administration of synthetic small interfering RNAs (siRNAs) effectively silences
hepatocyte gene expression in rodents and primates,,. Whether or not in vivo gene silencing …

MicroRNAs (miRNA) comprise an abundant class of small noncoding RNAs that act as
important posttranscriptional regulators of gene expression. Accumulating evidence …

The challenge of understanding the widespread biological roles of animal microRNAs
(miRNAs) has prompted the development of genetic and functional genomics technologies …

Abstract MicroRNA-122 (miR-122) is an abundant liver-specific miRNA, implicated in fatty
acid and cholesterol metabolism as well as hepatitis C viral replication. Here, we report that …

MicroRNAs (miRNAs) regulate many aspects of human biology. They target mRNAs for
translational repression or degradation through base pairing with 3′ untranslated regions …

Understanding the function of individual microRNA (miRNA) species in mice would require
the production of hundreds of loss-of-function strains. To accelerate analysis of miRNA …

Studying microRNA function in vivo requires genetic strategies to generate loss-of-function
phenotypes. We used lentiviral vectors to stably and specifically knock down microRNA by …

The opportunity to harness the RNA interference (RNAi) pathway to silence disease-causing
genes holds great promise for the development of therapeutics directed against targets that …