Laminins and their receptors in the CNS
Laminin, an extracellular matrix protein, is widely expressed in the central nervous system
(CNS). By interacting with integrin and non‐integrin receptors, laminin exerts a large variety …
(CNS). By interacting with integrin and non‐integrin receptors, laminin exerts a large variety …
Cell-specific expression and function of laminin at the neurovascular unit
Laminin, a major component of the basal lamina (BL), is a heterotrimeric protein with many
isoforms. In the CNS, laminin is expressed by almost all cell types, yet different cells …
isoforms. In the CNS, laminin is expressed by almost all cell types, yet different cells …
The importance of laminin at the blood-brain barrier
The blood-brain barrier is a unique property of central nervous system blood vessels that
protects sensitive central nervous system cells from potentially harmful blood components …
protects sensitive central nervous system cells from potentially harmful blood components …
Human diseases reveal novel roles for neural laminins
H Colognato, ML Feltri - Trends in neurosciences, 2005 - cell.com
Extracellular matrix molecules such as laminins have a central role in regulating cell
behaviour. However, our understanding of their functions in the mammalian nervous system …
behaviour. However, our understanding of their functions in the mammalian nervous system …
Laminin: loss-of-function studies
Y Yao - Cellular and Molecular Life Sciences, 2017 - Springer
Laminin, one of the most widely expressed extracellular matrix proteins, exerts many
important functions in multiple organs/systems and at various developmental stages …
important functions in multiple organs/systems and at various developmental stages …
[PDF][PDF] Laminin: structure, functions and receptors
HK Kleinman, BS Weeks - Current opinion in cell biology, 1989 - academia.edu
Laminin: structure, functions and receptors Page 1 Laminin: structure, functions and receptors
Introduction HK Kleinman and BS Weeks Laboratory of Developmental Biology and Anomalies …
Introduction HK Kleinman and BS Weeks Laboratory of Developmental Biology and Anomalies …
[HTML][HTML] Cortical deficiency of laminin γ1 impairs the AKT/GSK-3β signaling pathway and leads to defects in neurite outgrowth and neuronal migration
ZL Chen, V Haegeli, H Yu, S Strickland - Developmental biology, 2009 - Elsevier
Laminins have dramatic and varied actions on neurons in vitro. However, their in vivo
function in brain development is not clear. Here we show that knockout of laminin γ1 in the …
function in brain development is not clear. Here we show that knockout of laminin γ1 in the …
Laminin receptors: achieving specificity through cooperation
AM Mercurio - Trends in cell biology, 1995 - cell.com
The laminins are a large family of extracellular matrix proteins that can profoundly influence
development, differentiation and disease progression. The biological effects of the laminins …
development, differentiation and disease progression. The biological effects of the laminins …
Functional sites in the laminin alpha chains
N Suzuki, F Yokoyama, M Nomizu - Connective tissue research, 2005 - Taylor & Francis
Laminins, heterotrimers composed of α, β, and γ chains, are multifunctional glycoproteins
present in basement membranes. Laminins, the most important component of basement …
present in basement membranes. Laminins, the most important component of basement …
Laminin regulates oligodendrocyte development and myelination
Oligodendrocytes are the cells that myelinate axons and provide trophic support to neurons
in the CNS. Their dysfunction has been associated with a group of disorders known as …
in the CNS. Their dysfunction has been associated with a group of disorders known as …