Visual information is conveyed from the eye to the brain through the axons of retinal
ganglion cells (RGCs) that course through the optic nerve and synapse onto neurons in …

Axons of adult neurons in the mammalian central nervous system generally fail to
regenerate by themselves, and few if any therapeutic options exist to reverse this situation …

Like other neurons of the central nervous system (CNS), retinal ganglion cells (RGCs) are
normally unable to regenerate injured axons and instead undergo apoptotic cell death. This …

Axonal injury in the optic nerve is associated with retinal ganglion cell (RGC) degeneration
and irreversible loss of vision. However, inflammatory stimulation (IS) by intravitreal injection …

The optic nerve, like most pathways in the mature central nervous system, cannot
regenerate if injured, and within days, retinal ganglion cells (RGCs), the neurons that extend …

Retinal ganglion cell (RGC) function in health and disease: RGCs are extremely high-
maintenance neurons connecting the eye to the brain trough the optic nerve. In order to …

Retinal ganglion cells (RGCs) and their projections in the optic nerve offer a convenient
model to study survival and regeneration of mammalian central nervous system (CNS) nerve …

Mammalian retinal ganglion cells (RGCs) in the central nervous system (CNS) often die after
optic nerve injury and surviving RGCs fail to regenerate their axons, eventually resulting in …

Purpose.: To describe how developing amacrine cells and retinal ganglion cells (RGCs)
differ in survival signaling and global gene expression. Methods.: Amacrine cells were …

The wiring of visual circuits requires that retinal neurons functionally connect to specific
brain targets, a process that involves activity-dependent signaling between retinal axons …