It is well accepted that Th17 cells are a highly plastic cell subset that can be easily directed
toward the Th1 phenotype in vitro and also in vivo during inflammation. However, there is an …

Eomesodermin (Eomes) is a transcription factor (TF) of the T‐box family closely related to T‐
bet known for its role in CD8 T cell and natural killer cell differentiation. However, the role of …

Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …

Abstract The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able
to develop into other different lineage subsets, including the Th1-like Th17 cells. These cells …

The discovery of Th17 cell plasticity, in which CD4+ IL-17–producing Th17 cells give rise to
IL-17/IFN-γ double-producing cells and Th1-like IFNγ+ ex-Th17 lymphocytes, has raised …

TH17 cells are recognized as a unique subset of T helper cells that have critical roles in the
pathogenesis of autoimmunity and tissue inflammation. Although RORγt is necessary for the …

Th1 and Th17 cells are distinct lineages of effector/memory cells, imprinted for re‐
expression of IFN‐γ and IL‐17, by upregulated expression of T‐bet and retinoic acid‐related …

Discovery of the T‐helper 17 (Th17) subset heralded a major shift in T‐cell biology and
immune regulation. In addition to defining a new arm of the adaptive immune response …

Th17 cells were identified as an independent lineage of CD4+ T cells that secrete a
distinctive set of immunoregulatory cytokines, including IL‐17A, IL‐17F, IL‐22, and IL‐21 …

After activation, CD4+ helper T (Th) cells differentiate into cytokine-secreting effector
subsets. A novel subset of CD4+ helper T (Th) cells that produce two related cytokines IL-17 …