Event timing at the single-cell level

E Yurkovsky, I Nachman - Briefings in functional genomics, 2013 - academic.oup.com
The timing of a cellular event often hides critical information on the process leading to the
event. Our ability to measure event times in single cells along with other quantities allow us …

Cross-species comparisons and in vitro models to study tempo in development and homeostasis

T Rayon, J Briscoe - Interface Focus, 2021 - royalsocietypublishing.org
Time is inherent to biological processes. It determines the order of events and the speed at
which they take place. However, we still need to refine approaches to measure the course of …

[PDF][PDF] SnapShot: timescales in cell biology

M Shamir, Y Bar-On, R Phillips, R Milo - Cell, 2016 - cell.com
Knowing key timescales enables us to quickly gain intuition, perform sanity checks and
serves as a sixth sense in understanding how cells grow and communicate. This SnapShot …

Cell time: How cells control developmental timetables

T Rayon - Science Advances, 2023 - science.org
Cell time: How cells control developmental timetables | Science Advances news careers
commentary Journals Science Science brought to you byGoogle Indexer Log in science science …

The emergence and promise of single-cell temporal-omics approaches

AR Lederer, G La Manno - Current opinion in biotechnology, 2020 - Elsevier
Highlights•Pseudotime trajectory inference algorithms harness the variance of
asynchronously changing cells.•RNA velocity uses expression dynamics to extrapolate …

Biological timekeeping in the presence of stochasticity

F Jafarpour, M Vennettilli, S Iyer-Biswas - arXiv preprint arXiv:1703.10058, 2017 - arxiv.org
Causal ordering of key events in the cell cycle is essential for proper functioning of an
organism. Yet, it remains a mystery how a specific temporal program of events is maintained …

A stochastic vs deterministic perspective on the timing of cellular events

L Ham, MA Coomer, K Öcal, R Grima… - Nature …, 2024 - nature.com
Cells are the fundamental units of life, and like all life forms, they change over time. Changes
in cell state are driven by molecular processes; of these many are initiated when molecule …

Control strategies for the timing of intracellular events

M Cao, B Qiu, T Zhou, J Zhang - Physical Review E, 2019 - APS
While the timing of intracellular events is essential for many cellular processes, gene
expression inside a single cell can exhibit substantial cell-to-cell variability, raising the …

Generating kinetic environments to study dynamic cellular processes in single cells

A Thiemicke, H Jashnsaz, G Li, G Neuert - Scientific reports, 2019 - nature.com
Cells of any organism are consistently exposed to changes over time in their environment.
The kinetics by which these changes occur are critical for the cellular response and fate …

Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages

S Chakrabarti, AL Paek, J Reyes, KA Lasick… - Nature …, 2018 - nature.com
The origin of lineage correlations among single cells and the extent of heterogeneity in their
intermitotic times (IMT) and apoptosis times (AT) remain incompletely understood. Here we …