A complex formed by human α-lactalbumin (α-LA) and oleic acid (OA), named HAMLET, has
been shown to have an apoptotic activity leading to the selective death of tumor cells. In …

Thirteen years ago, α‐lactalbumin (α‐LA) was first reported to form a complex with oleic acid
(OA). This complex, called HAMLET (human α‐lactalbumin made lethal to tumour cells), was …

The complexes formed by partially folded human and bovine α‐lactalbumin with oleic acid
(OA) have been reported to display selective apoptotic activity against tumor cells. These …

α-Lactalbumin (LA) forms with oleic acid (OA) a complex which has been reported to induce
the selective death of tumor cells. However, the mechanism by which this complex kills a …

Human α‐lactalbumin made lethal to tumor cells (HAMLET) and equine lysozyme with oleic
acid (ELOA) are complexes consisting of protein and fatty acid that exhibit cytotoxic …

Oleic acid (OA) is a monounsaturated fatty acid that upon binding to milk proteins, such as α-
lactalbumin and lactoferrin, forms potent complexes, which exert selective anti-tumor activity …

A complex of α‐lactalbumin and oleic acid has previously been shown to induce apoptosis
in cancer cells in a number of in vitro and in vivo trials. This complex is called HAMLET or …

It was recently shown that α-lactalbumin associated with oleic acid (HAMLET) interacts with
core histones thereby triggering apoptosis of tumor cells (J. Biol. Chem. 2003, 278, 42131) …

HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a complex between α-
lactalbumin and oleic acid that induces apoptosis in tumor cells, but not in healthy cells …

Complexes of the milk protein, α‐lactalbumin, and the fatty acid, oleic acid, have previously
been shown to be cytotoxic. Complexes of α‐lactalbumin and five different fatty acids …