Endometrial carcinoma: molecular alterations involved in tumor development and progression

A Yeramian, G Moreno-Bueno, X Dolcet, L Catasus… - Oncogene, 2013 - nature.com
In the western world, endometrial carcinoma (EC) is the most common cancer of the female
genital tract. The annual incidence has been estimated at 10–20 per 100 000 women. Two …

Endometrial carcinoma: pathology and genetics

J Prat, A Gallardo, M Cuatrecasas, L Catasús - Pathology, 2007 - Taylor & Francis
In the Western world, endometrial carcinoma is the most common malignant tumour of the
female genital tract and the fourth most common cancer in women after carcinomas of …

Molecular and pathologic aspects of endometrial carcinogenesis

JL Hecht, GL Mutter - Journal of clinical oncology, 2006 - ascopubs.org
Endometrial cancer is the most common gynecological malignancy, with 41,000 new cases
projected in the United States for 2006. Two different clinicopathologic subtypes are …

Endometrial carcinoma

A Di Cristofano, LH Ellenson - Annu. Rev. Pathol. Mech. Dis., 2007 - annualreviews.org
Endometrial carcinoma, a common malignancy of the female genital tract, is composed of a
number of tumor types with different light-microscopic features, molecular genetic …

Pathology of endometrial carcinoma

SF Lax - Molecular Genetics of Endometrial Carcinoma, 2017 - Springer
On a clinicopathological and molecular level, two distinctive types of endometrial carcinoma,
type I and type II, can be distinguished. Endometrioid carcinoma, the typical type I …

Molecular classification and emerging targeted therapy in endometrial cancer

TT Yen, TL Wang, AN Fader, IM Shih… - International Journal of …, 2020 - journals.lww.com
Recent advances in molecular studies, especially genome-wide analyses, have revealed
the landscape of genomic alterations present in endometrial carcinomas, and have provided …

Molecular pathology of endometrial carcinoma, Transcriptional signature in endometrioid tumors

M Abal, J Planaguma, A Gil-Moreno… - Histology and …, 2006 - digitum.um.es
A dualistic model, which has been established on a morphological basis and that
differentiates type I endometrioid from type II nonendometrioid endometrial cancer, is widely …

Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints

D Llobet, J Pallarés, A Yeramian… - Journal of clinical …, 2009 - jcp.bmj.com
This article reviews the main molecular alterations involved in endometrial carcinoma. Five
molecular features (microsatellite instability, and mutations in the PTEN, k-RAS, PIK3CA and …

Endometrioid carcinoma of the endometrium: pathologic and molecular features

A Azueta, S Gatius, X Matias-Guiu - Seminars in diagnostic pathology, 2010 - Elsevier
Endometrioid carcinoma of the endometrium is the most common type of endometrial
carcinoma. The microscopic appearance of the tumor resembles that of the proliferative …

Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification

SF Lax - Virchows Archiv, 2004 - Springer
Two types of endometrial carcinoma are distinguished with respect to biology and clinical
course. Type-I carcinoma is related to hyperestrogenism by association with endometrial …