1H HR-MAS NMR Spectroscopy of Tumor-Induced Local Metabolic “Field-Effects” Enables Colorectal Cancer Staging and Prognostication

B Jiménez, R Mirnezami, J Kinross… - Journal of proteome …, 2013 - ACS Publications
Colorectal cancer (CRC) is a major cause of morbidity and mortality in developed countries.
Despite operative advances and the widespread adoption of combined-modality treatment …

Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas …

ECY Chan, PK Koh, M Mal, PY Cheah… - Journal of proteome …, 2009 - ACS Publications
Current clinical strategy for staging and prognostication of colorectal cancer (CRC) relies
mainly upon the TNM or Duke system. This clinicopathological stage is a crude prognostic …

Rapid diagnosis and staging of colorectal cancer via high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy of intact tissue …

R Mirnezami, B Jiménez, JV Li, JM Kinross… - Annals of …, 2014 - journals.lww.com
Objective: To develop novel metabolite-based models for diagnosis and staging in
colorectal cancer (CRC) using high-resolution magic angle spinning nuclear magnetic …

1H NMR‐based metabolomics reveal overlapping discriminatory metabolites and metabolic pathway disturbances between colorectal tumor tissues and fecal …

Y Lin, C Ma, T Bezabeh, Z Wang… - … Journal of Cancer, 2019 - Wiley Online Library
Previous studies have compared fecal metabolites from healthy and colorectal cancer
(CRC) patients to predict the pro‐CRC signatures. However, the systemic mechanistic link …

[HTML][HTML] Chemical mapping of the colorectal cancer microenvironment via MALDI imaging mass spectrometry (MALDI-MSI) reveals novel cancer-associated field …

R Mirnezami, K Spagou, PA Vorkas, MR Lewis… - Molecular …, 2014 - Elsevier
Matrix-assisted laser desorption ionisation imaging mass spectrometry (MALDI-MSI) is a
rapidly advancing technique for intact tissue analysis that allows simultaneous localisation …

Discrimination of Healthy and Neoplastic Human Colon Tissues by ex Vivo HR-MAS NMR Spectroscopy and Chemometric Analyses

V Righi, C Durante, M Cocchi… - Journal of Proteome …, 2009 - ACS Publications
The metabolic profile of human healthy and neoplastic colorectal tissues was obtained using
ex vivo High-Resolution Magic Angle Spinning (HR-MAS) NMR spectroscopy. Principal …

Metabolic characterization of primary human colorectal cancers using high resolution magic angle spinning 1H magnetic resonance spectroscopy

M Piotto, FM Moussallieh, B Dillmann, A Imperiale… - Metabolomics, 2009 - Springer
Colorectal cancer is one of the most frequent and most lethal forms of cancer in the western
world. The aim of this study is to characterize by 1 H high resolution magic angle spinning …

Characterizing metabolic changes in human colorectal cancer

MD Williams, X Zhang, JJ Park, WF Siems… - Analytical and …, 2015 - Springer
Colorectal cancer (CRC) remains a leading cause of cancer death worldwide, despite the
fact that it is a curable disease when diagnosed early. The development of new screening …

Metabolomic NMR fingerprinting to identify and predict survival of patients with metastatic colorectal cancer

I Bertini, S Cacciatore, BV Jensen, JV Schou… - Cancer research, 2012 - AACR
Earlier detection of patients with metastatic colorectal cancer (mCRC) might improve their
treatment and survival outcomes. In this study, we used proton nuclear magnetic resonance …

Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle …

T Seierstad, K Røe, B Sitter, J Halgunset, K Flatmark… - Molecular Cancer, 2008 - Springer
Background This study was conducted in order to elucidate metabolic differences between
human rectal cancer biopsies and colorectal HT29, HCT116 and SW620 xenografts by …