The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

ABSTRACT Introduction: Cancer associated fibroblasts (CAFs) are the largest population of
stromal cells in breast tumors. Emerging evidence has suggested that CAFs are important …

Cancerous tissue is a complex mix of tumor cells, stromal cells and extracellular matrix
(ECM), all of which make up a disordered and aggressive niche in comparison with …

Simple Summary Breast cancer is a major public health problem with a large impact on the
life of patients and their families. It is a highly curable disease when detected early, and an …

Tumor cells exist in close proximity with non-malignant cells. Extensive and multilayered
crosstalk between tumor cells and stromal cells tailors the tumor microenvironment (TME) to …

Stromal heterogeneity of tumor microenvironment (TME) plays a crucial role in malignancy
and therapeutic resistance. Cancer-associated fibroblasts (CAFs) are one of the major …

Breast cancer is the most common malignant tumor in women, and the incidence of this
disease has increased in recent years because of changes in diet, living environment …

Breast cancer is one of the most important women-related malignancies, which is incurable
(particularly in advanced stages) and tumor microenvironment is a number one accused part …

Simple Summary Drug resistance and insensitivity to treatments are the main challenges in
breast cancer therapy. Cancer-associated fibroblasts (CAFs) are heterogeneous stromal …

Cancers are heterogeneous tissues comprised of multiple components, including tumor
cells and microenvironment cells. The tumor microenvironment has a critical role in tumor …