Pain and analgesia: The dual effect of nitric oxide in the nociceptive system

Y Cury, G Picolo, VP Gutierrez, SH Ferreira - Nitric oxide, 2011 - Elsevier
Nitric oxide (NO) is involved in many physiological processes and several lines of evidence
have indicated that NO plays a complex and diverse role in the modulation of pain. Nitric …

Nitric oxide and pain:'Something old, something new'

A Miclescu, T Gordh - Acta Anaesthesiologica Scandinavica, 2009 - Wiley Online Library
Challenges have emerged following the revival of nitric oxide (NO) from 'something old', a
simple gas derived from nitrogen and oxygen with a role in the early stages of evolution, into …

Nitric oxide mediates behavioral signs of neuropathic pain in an experimental rat model

YW Yoon, B Sung, JM Chung - Neuroreport, 1998 - journals.lww.com
THIS study was conducted to determine whether nitric oxide (NO) is involved in the
maintenance of behavioral signs of neuropathic pain induced by tightly ligating the left L5 …

The role of nitric oxide in nociception

ZD Luo, D Cizkova - Current review of pain, 2000 - Springer
Pharmacologic, electrophysiologic, and immunohistochemical studies have suggested a
role of nitric oxide (NO) in nociception processing. Recent studies have indicated that NO …

Role of nitric oxide in the physiopathology of pain

M Anbar, BM Gratt - Journal of pain and symptom management, 1997 - Elsevier
Many painful disorders, including joint dysfunctions such as rheumatoid arthritis (RA) or
temporomandibular joint disorders (TMD), are associated with hyperthermia of the overlying …

[HTML][HTML] Pain modulation by nitric oxide in the spinal cord.

MAM Freire, JS Guimarães, W Gomes-Leal… - Frontiers in …, 2009 - frontiersin.org
Nitric oxide (NO) is a versatile messenger molecule first associated with endothelial relaxing
effects. In the central nervous system (CNS), NO synthesis is primarily triggered by activation …

Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats

AK Naik, SK Tandan, D Kumar… - European journal of …, 2006 - Elsevier
This study was conducted to examine the role of nitric oxide (NO) in peripheral neuropathy
induced by chronic constriction injury of sciatic nerve of rats by using NO precursor, NO …

Nitric oxide evokes pain in humans on intracutaneous injection

H Holthusen, JO Arndt - Neuroscience letters, 1994 - Elsevier
To test the hypothesis that nitric oxide (NO) acts algetically in humans, we determined pain
intensity/dose relations for intracutaneously applied NO solutions. NO, dissolved in …

NO pain: potential roles of nitric oxide in neuropathic pain

D Levy, DW Zochodne - Pain Practice, 2004 - Wiley Online Library
The disabling human syndrome of “neuropathic pain” is an intractable complication of
peripheral nerve injury or degeneration. A complex interaction between injured peripheral …

Nitric oxide and opioid tolerance

AM Babey, Y Kolesnikov, J Cheng, CE Inturrisi… - …, 1994 - Elsevier
Under conditions in which N G-nitro-l-arginine (NOArg) treatment prevents morphine
tolerance, NOArg induces a slow progressive inhibition of nitric oxide synthase (NOS) …