Context Antihypertensive therapy is well established to reduce hypertension-related
morbidity and mortality, but the optimal first-step therapy is unknown. Objective To determine …

The Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT)
provides a unique opportunity to compare the long-term relative safety and efficacy of …

Evidence that new antihypertensives are superior to older drugs - The Lancet Skip to Main
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Background This study was performed to determine whether, in high-risk hypertensive
patients with a reduced glomerular filtration rate (GFR), treatment with a calcium channel …

Background: Chronic kidney disease is common in older patients with hypertension.
Objective: To compare rates of coronary heart disease (CHD) and end-stage renal disease …

Diuretics and β-blockers have been shown to reduce the risk of cardiovascular morbidity
and mortality in people with hypertension in long-term clinical trials. No study has compared …

We investigated whether protection from coronary heart disease (CHD) and stroke conferred
by angiotensin-converting enzyme inhibitors (ACEIs) and calcium channel blockers (CCBs) …

Importance Antihypertension medications have been associated with prevention of
cardiovascular events, although less is known about the comparative effectiveness of …

Are newer types of antihypertensive agents, which are currently more costly to purchase on
average, as good or better than diuretics in reducing coronary heart disease incidence and …

Background We conducted a systematic review of evidence from randomized controlled
trials to answer the following research question: What are the relative effects of different …