[HTML][HTML] Evaluation of sucrose laurate as an intestinal permeation enhancer for macromolecules: ex vivo and in vivo studies
F McCartney, M Rosa, DJ Brayden - Pharmaceutics, 2019 - mdpi.com
Oral delivery of macromolecules requires permeation enhancers (PEs) adaptable to
formulation. Sucrose laurate (SL)(D1216), a food grade surfactant, was assessed in Caco-2 …
formulation. Sucrose laurate (SL)(D1216), a food grade surfactant, was assessed in Caco-2 …
[HTML][HTML] Permeability-enhancing effects of three laurate-disaccharide monoesters across isolated rat intestinal mucosae
Abstract Laurate (C 12)-sucrose esters are established intestinal epithelial permeation
enhancers (PEs) with potential for use in oral delivery. Most studies have examined blends …
enhancers (PEs) with potential for use in oral delivery. Most studies have examined blends …
Effects of surfactant-based permeation enhancers on mannitol permeability, histology, and electrogenic ion transport responses in excised rat colonic mucosae
Surfactant-based intestinal permeation enhancers (PEs) are constituents of several oral
macromolecule formulations in clinical trials. This study examined the interaction of a test …
macromolecule formulations in clinical trials. This study examined the interaction of a test …
Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: ex vivo and in vivo rat studies
F McCartney, V Jannin, S Chevrier… - Journal of Controlled …, 2019 - Elsevier
Abstract Labrasol® ALF (Labrasol®), is a non-ionic surfactant excipient primarily used as a
solubilising agent. It was investigated here as an intestinal permeation enhancer in isolated …
solubilising agent. It was investigated here as an intestinal permeation enhancer in isolated …
A permeation enhancer for increasing transport of therapeutic macromolecules across the intestine
Delivery of therapeutic macromolecules is limited by the physiological limitations of the
gastrointestinal tract including poor intestinal permeability, low pH and enzymatic activity …
gastrointestinal tract including poor intestinal permeability, low pH and enzymatic activity …
[HTML][HTML] Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)
Salcaprozate sodium (SNAC) and sodium caprate (C10) are two of the most advanced
intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery …
intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery …
Intestinal surfactant permeation enhancers and their interaction with enterocyte cell membranes in a mucosal explant system
EM Danielsen, GH Hansen - Tissue Barriers, 2017 - Taylor & Francis
Intestinal permeation enhancers (PEs) are agents aimed to improve oral delivery of
therapeutic drugs with poor bioavailability. The main permeability barrier for oral delivery is …
therapeutic drugs with poor bioavailability. The main permeability barrier for oral delivery is …
Safe and effective permeation enhancers for oral drug delivery
K Whitehead, N Karr, S Mitragotri - Pharmaceutical research, 2008 - Springer
Purpose The use of intestinal permeation enhancers to overcome the absorption challenges
associated with oral drug delivery has been hampered by the notion that enhancer efficacy …
associated with oral drug delivery has been hampered by the notion that enhancer efficacy …
[HTML][HTML] Probing the action of permeation enhancers sodium cholate and N-dodecyl-β-D-maltoside in a porcine jejunal mucosal explant system
EM Danielsen, GH Hansen - Pharmaceutics, 2018 - mdpi.com
The small intestinal epithelium constitutes a major permeability barrier for the oral
administration of therapeutic drugs with poor bioavailability, and permeation enhancers …
administration of therapeutic drugs with poor bioavailability, and permeation enhancers …
[HTML][HTML] Synthesis, structure–activity relationships and in vitro toxicity profile of lactose-based fatty acid monoesters as possible drug permeability enhancers
Permeability enhancers are receiving increased attention arising from their ability to
increase transepithelial permeability and thus, bioavailability of orally or pulmonary …
increase transepithelial permeability and thus, bioavailability of orally or pulmonary …