Nucleic acid drugs—current status, issues, and expectations for exosomes

Y Yamada - Cancers, 2021 - mdpi.com
Simple Summary Nucleic acid drugs provide novel therapeutic modalities with
characteristics that differ from those of small molecules and antibodies. In this review, I focus …

Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)

W Ke, KA Afonin - Advanced drug delivery reviews, 2021 - Elsevier
With recent advances in nanotechnology and therapeutic nucleic acids (TNAs), various
nucleic acid nanoparticles (NANPs) have demonstrated great promise in diagnostics and …

The advances and challenges in utilizing exosomes for delivering cancer therapeutics

M Yang, SY Wu - Frontiers in pharmacology, 2018 - frontiersin.org
Nanotechnology plays an important role in advancing treatment and diagnosis of a variety of
human diseases. The use of nanocarriers often leads to better pharmacokinetic and safety …

Exosomes and the emerging field of exosome-based gene therapy

AJ O'Loughlin, CA Woffindale… - Current gene …, 2012 - ingentaconnect.com
Exosomes are a subtype of membrane vesicle released from the endocytic compartment of
live cells. They play an important role in endogenous cell-to-cell communication. Previously …

Exosome-like nanovectors for drug delivery in cancer

N Arrighetti, C Corbo, M Evangelopoulos… - Current medicinal …, 2019 - ingentaconnect.com
Cancer treatment still represents a formidable challenge, despite substantial advancements
in available therapies being made over the past decade. One major issue is poor …

Recent advances in exosome-based drug delivery for cancer therapy

H Kim, H Jang, H Cho, J Choi, KY Hwang, Y Choi… - Cancers, 2021 - mdpi.com
Simple Summary Exosomes derived from various sources can deliver therapeutic agents
such as small molecule drugs, nucleic acids, and proteins to cancer cells by passive or …

Exosomes as a drug delivery tool for cancer therapy: A new era for existing drugs and oncolytic viruses

Y Kakiuchi, S Kuroda, N Kanaya… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Exosomes are cell-derived nanovesicles involved in cell-to-cell
communications. These nanovesicles are generally considered to contain important carriers …

Exosomes as drug carriers for cancer therapy

JE Pullan, MI Confeld, JK Osborn, J Kim… - Molecular …, 2019 - ACS Publications
Exosomes, biological extracellular vesicles, have recently begun to find use in targeted drug
delivery in solid tumor research. Ranging from 30–120 nm in size, exosomes are secreted …

A comprehensive overview of exosomes as drug delivery vehicles—endogenous nanocarriers for targeted cancer therapy

KB Johnsen, JM Gudbergsson, MN Skov… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Exosomes denote a class of secreted nanoparticles defined by size, surface protein and
lipid composition, and the ability to carry RNA and proteins. They are important mediators of …

Delivery of oligonucleotide therapeutics: chemical modifications, lipid nanoparticles, and extracellular vesicles

JP Bost, H Barriga, MN Holme, A Gallud, M Maugeri… - ACS …, 2021 - ACS Publications
Oligonucleotides (ONs) comprise a rapidly growing class of therapeutics. In recent years, the
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …