KDM5B histone demethylase is overexpressed in many cancers and plays an ambivalent
role in oncogenesis, depending on the specific context. This ambivalence could be …

Mammalian histone demethylases of the KDM5 family are mediators of gene expression
dynamics during developmental, cellular differentiation, and other nuclear processes. They …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Histone methylation status is an important process associated with cell growth, survival,
differentiation and gene expression in human diseases. As a member of the KDM4 family …

Background Although an increasing number of histone demethylases have been identified
and biochemically characterized, their biological functions largely remain uncharacterized …

Distinct epigenetic modifiers ensure coordinated control over genes that govern a myriad of
cellular processes. Growing evidence shows that dynamic regulation of histone methylation …

Histone posttranslational modifications are important components of epigenetic regulation.
One extensively studied modification is the methylation of lysine residues. These …

Lysine-specific demethylase 5A (KDM5A), an enzyme that removes activating H3K4 di-and
trimethylation marks, plays critical roles in controlling transcription and chromatin …

Localized chromatin modifications of histone tails play an important role in regulating gene
transcription, and aberration of these processes leads to carcinogenesis. Methylated histone …

Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …