Molecular aspects of malaria pathogenesis

N Rasti, M Wahlgren, Q Chen - FEMS Immunology & Medical …, 2004 - academic.oup.com
Plasmodium falciparum being the most lethal plasmodiae is still a major cause of the
disease burden and mortality in malaria endemic areas. Due to the wide spread drug …

Molecular aspects of severe malaria

Q Chen, M Schlichtherle… - Clinical microbiology …, 2000 - Am Soc Microbiol
Human infections with Plasmodium falciparum may result in severe forms of malaria. The
widespread and rapid development of drug resistance in P. falciparum and the resistance of …

Malaria pathogenesis: a jigsaw with an increasing number of pieces

A Heddini - International journal for parasitology, 2002 - Elsevier
Plasmodiumfalciparum malaria remains as one of the most devastating global health
problems of today. It is estimated that around 150 million individuals get the disease every …

[HTML][HTML] In vivo transcriptional profiling of Plasmodium falciparum

JP Daily, KG Le Roch, O Sarr, X Fang, Y Zhou, O Ndir… - Malaria journal, 2004 - Springer
Background Both host and pathogen factors contribute to disease outcome in Plasmodium
falciparum infection. The feasibility of studying the P. falciparum in vivo transcriptome to …

[HTML][HTML] The role of different components of the immune system against Plasmodium falciparum malaria: Possible contribution towards malaria vaccine development

WL Mandala, V Harawa, F Dzinjalamala… - Molecular and …, 2021 - Elsevier
Plasmodium falciparum malaria still remains a major global public health challenge with
over 220 million new cases and well over 400,000 deaths annually. Most of the deaths occur …

New insights into malaria pathogenesis

CA Moxon, MP Gibbins, D McGuinness… - Annual Review of …, 2020 - annualreviews.org
Malaria remains a major public health threat in tropical and subtropical regions across the
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …

[HTML][HTML] Molecular basis for evasion of host immunity and pathogenesis in malaria

R Ramasamy - Biochimica Et Biophysica Acta (BBA)-Molecular Basis …, 1998 - Elsevier
The article relates the ability of the malaria parasite Plasmodium falciparum to avoid a
protective immune response, and to induce pathological changes, to the properties of …

Antigenic variation and immune evasion in Plasmodium falciparum malaria

JC Reeder, GV Brown - Immunology and Cell Biology, 1996 - Wiley Online Library
Plasmodium falciparum malaria is responsible for 2 million deaths each year. Even in
endemic regions, immunity to malaria builds slowly and is rarely complete. Strategies such …

Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling

K Witmer, CD Schmid, NMB Brancucci… - Molecular …, 2012 - Wiley Online Library
The Plasmodium falciparum genome is equipped with several subtelomeric gene families
that are implicated in parasite virulence and immune evasion. Members of these families are …

Pathogenesis of Plasmodium falciparum malaria: the roles of parasite adhesion and antigenic variation

JG Beeson, GV Brown - Cellular and Molecular Life Sciences CMLS, 2002 - Springer
Malaria results in up to 2.5 million deaths annually, with young children and pregnant
women at greatest risk. The great majority of severe disease is caused by Plasmodium …