A novel pathway of vitamin D activation by CYP11A has previously been elucidated. To
define the mechanism of action of its major dihydroxy-products, we tested the divergence …

Human keratinocytes convert 25 (OH) D3 to hormonally active 1α, 25 (OH) 2D3 and respond
to its antiproliferative/prodifferentiating action in vitro and in vivo. Levels and activity of 1α, 25 …

Research over the last decade has revealed that CYP11A1 can hydroxylate the side chain
of vitamin D3 at carbons 17, 20, 22 and 23 to produce at least 10 metabolites, with 20 (OH) …

It has been shown that mammalian cytochrome P450scc can metabolize vitamin D3 to 20-
hydroxyvitamin D3 (20 (OH) D3) and 20, 22 (OH) 2D3. To define the biological significance …

Cytochrome P450scc (CYP11A1) can hydroxylate vitamin D3, producing 20 S-
hydroxyvitamin D3 [20 (OH) D3] and 20 S, 23-dihydroxyvitamin D3 [20, 23 (OH) 2D3] as the …

Human keratinocytes are fully competent cells of the vitamin D (VD) hormone system. They
have the capacity to generate VD, to convert it to hormonally active 1α, 25 (OH) 2D3 and …

CYP11A1 hydroxylates the side chain of vitamin D3 (D3) in a sequential fashion [D3→ 20S
(OH) D3→ 20, 23 (OH) 2 D3→ 17, 20, 23 (OH) 3 D3], in an alternative to the classical …

The current understanding of the vitamin D3 system shows skin as the unique site of vitamin
D3 production and liver is thought to be the main site of conversion to 25 (OH) D3. Skin is …

We investigated the metabolism of vitamin D2 to hydroxyvitamin D2 metabolites ((OH) D2)
by human placentas ex-utero, adrenal glands ex-vivo and cultured human epidermal …

We have examined effects of the 20, 23‐dihydroxyvitamin D3 (20, 23 (OH) 2D3), on
differentiation and proliferation of human keratinocytes and the anti‐inflammatory potential …