Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in
amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron …

In amyotrophic lateral sclerosis (ALS) motor neurons (MNs) undergo dying-back, where the
distal axon degenerates before the soma. The hexanucleotide repeat expansion (HRE) in …

Mutations in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis
(ALS). Accumulating evidence implicates astrocytes as important non‐cell autonomous …

Objective How hexanucleotide (GGGGCC) repeat expansions in C9ORF72 cause
amyotrophic lateral sclerosis (ALS) remains poorly understood. Both gain‐and loss‐of …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with diverse etiologies.
Therefore, the identification of common disease mechanisms and therapeutics targeting …

Hexanucleotide repeat expansions in C9orf72 are the most common cause of familial
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mechanisms by …

Objective To define the role that repeat expansions of a GGGGCC hexanucleotide sequence
of the C9orf72 gene play in the pathogenesis of amyotrophic lateral sclerosis (ALS) and …

Amyotrophic lateral sclerosis (ALS) is an aggressive neurodegenerative disorder that
orchestrates an attack on the motor nervous system that is unrelenting. Recent discoveries …

It is important to understand how the disease process affects the metabolic pathways in
amyotrophic lateral sclerosis and whether these pathways can be manipulated to ameliorate …

GGGGCC repeat expansions in C9ORF72 are the most common genetic cause of both ALS
and FTD. To uncover underlying pathogenic mechanisms, we found that DNA damage was …