BACKGROUND & AIMS: Polymorphisms in the IL28B gene have been associated with
clearance of hepatitis C virus (HCV), indicating a role for type III interferons (IFNs) in HCV …

Early, vigorous intrahepatic induction of interferon (IFN)‐stimulated gene (ISG) induction is a
feature of hepatitis C virus (HCV) infection, even though HCV inhibits the induction of type I …

Several genome‐wide association studies (GWAS) have identified a genetic polymorphism
associated with the gene locus for interleukin 28B (IL28B), a type III interferon (IFN), as a …

Hepatitis C virus (HCV) infections become chronic in the majority of infected individuals, and
chronic hepatitis C (CHC) can lead to cirrhosis and hepatocellular carcinoma. The innate …

Treatment-induced control and spontaneous clearance of hepatitis C virus (HCV) infection
are affected by various host factors. Polymorphisms in the region of the gene IL28B are …

BACKGROUND & AIMS: Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of
infected persons; approximately 50% of these do not respond to therapy. We performed a …

Innate immunity plays an important role in host antiviral response to hepatitis C viral (HCV)
infection. Recently, single nucleotide polymorphisms (SNPs) of IL28B and host response to …

Genetic variation in the IL28B (interleukin 28B; interferon lambda 3) region has been
associated with sustained virological response (SVR) rates in patients with chronic hepatitis …

Recent studies have shown that a single‐nucleotide polymorphism upstream of the
interleukin‐28B (IL28B) gene plays a major role in predicting therapeutic response in …

Type III IFNs are important mediators of antiviral immunity. IFN-λ4 is a unique type III IFN
because it is produced only in individuals who carry a dG allele of a genetic variant …