Interactions between endothelial cells (ECs) and perivascular mural cells (MCs) via
signaling molecules or physical contacts are implicated both in vascular remodeling and …

In this study, we used double transgenic mice with inducible expression of angiopoietin‐2
(Ang2) to investigate the role of Ang2 in the retinal and choroidal circulations and in three …

Abstract Angiopoietin 2 (Ang2) expression in the retina is increased during physiologic and
pathologic neovascularization suggesting that it may be involved. In this study, we used …

Several retinal and choroidal diseases are potentially treatable by intraocular delivery of
genes whose products may counter or neutralize abnormal gene expression that occurs as …

Our previous data suggested that angiopoietin-2 (Ang-2) is linked to pericyte loss, thereby
playing an important role in diabetic retinopathy. In this study, we investigated the effect of …

Mural cells are essential components of blood vessels and are necessary for normal
development, homeostasis, and organ function. Alterations in mural cell density or the stable …

Recent studies have shown that the angiopoietin-Tie2 system is a predominant regulator of
vascular integrity. In this study, we investigated the effect of two known angiogenic stimuli …

Vascular development in the embryo requires coordinated signaling through several
endothelial cell‐specific receptors; however, it is not known whether this is also required …

purpose. Ischemia-induced neovascularization can cause catastrophic loss of vision in
retinal disorders such as diabetic retinopathy. Recent studies have shown that the …

Diabetic retinopathy (DR) is the commonest cause of blindness in the working‐age
population of the developed world. The molecular pathophysiology of DR is complex, and a …