Highly Efficient Far‐Red/NIR‐Absorbing Neutral Ir (III) Complex Micelles for Potent Photodynamic/Photothermal Therapy

B Liu, J Jiao, W Xu, M Zhang, P Cui, Z Guo… - Advanced …, 2021 - Wiley Online Library
A critical issue in photodynamic therapy (PDT) is inadequate reactive oxygen species (ROS)
generation in tumors, causing inevitable survival of tumor cells that usually results in tumor …

An Iridium (III) complex bearing a Donor–Acceptor–Donor type ligand for NIR‐triggered dual phototherapy

J Zhao, K Yan, G Xu, X Liu, Q Zhao… - Advanced Functional …, 2021 - Wiley Online Library
Iridium (III) complexes are an important group of photosensitizers for photodynamic therapy
(PDT). This work constructs a donor–acceptor–donor structure‐based iridium (III) complex …

Iridium (III) complex–derived polymeric micelles with low dark toxicity and strong NIR excitation for phototherapy and chemotherapy

J Zhao, X Zhang, L Fang, C Gao, C Xu, S Gou - Small, 2020 - Wiley Online Library
Iridium (III) complexes are potent candidates for photodynamic therapy. However, their
clinical usage is impeded by their poor water solubility, high dark toxicity, and negligible …

Rational Design of IR820‐and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

X Hu, H Tian, W Jiang, A Song, Z Li, Y Luan - Small, 2018 - Wiley Online Library
Phototherapy as a promising cancer diagnostic and therapeutic strategy has aroused
extensive attention. However, single‐wavelength near‐infrared (NIR) light–triggered …

Exosome camouflaged coordination-assembled Iridium (III) photosensitizers for apoptosis-autophagy-ferroptosis induced combination therapy against melanoma

T Feng, Z Tang, J Karges, J Shen, C Jin, Y Chen, Y Pan… - Biomaterials, 2023 - Elsevier
Melanoma represents the most fatal form of skin cancer due to its resistance mechanisms
and high capacity for the development of metastases. Among other medicinal techniques …

Rationally designed long-wavelength absorbing Ru (II) polypyridyl complexes as photosensitizers for photodynamic therapy

J Karges, F Heinemann, M Jakubaszek… - Journal of the …, 2020 - ACS Publications
The utilization of photodynamic therapy (PDT) for the treatment of various types of cancer
has gained increasing attention over the last decades. Despite the clinical success of …

Near-infrared photosensitizers adaptive to tumor hypoxic microenvironment for synergistic photothermal-photodynamic and immunotherapy

X Meng, Y Han, S Wang, X Wang, Z Zhang, S Yao… - Nano Today, 2023 - Elsevier
For photodynamic therapy (PDT), traditional type II photosensitizers rely on local molecular
oxygen to produce highly cytotoxic singlet oxygen (1 O 2) to kill tumor cells, which is …

A supramolecular photosensitizer derived from an Arene-Ru (II) complex self-assembly for NIR activated photodynamic and photothermal therapy

G Xu, C Li, C Chi, L Wu, Y Sun, J Zhao, XH Xia… - Nature …, 2022 - nature.com
Effective photosensitizers are of particular importance for the widespread clinical utilization
of phototherapy. However, conventional photosensitizers are usually plagued by short …

A near-infrared light-activatable Ru (ii)-coumarin photosensitizer active under hypoxic conditions

E Ortega-Forte, A Rovira, M López-Corrales… - Chemical …, 2023 - pubs.rsc.org
Photodynamic therapy (PDT) represents a promising approach for cancer treatment.
However, the oxygen dependency of PDT to generate reactive oxygen species (ROS) …

Near-infrared absorbing Ru (ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma

LM Lifshits, JA Roque III, P Konda, S Monro… - Chemical …, 2020 - pubs.rsc.org
Mounting evidence over the past 20 years suggests that photodynamic therapy (PDT), an
anticancer modality known mostly as a local treatment, has the capacity to invoke a systemic …