Salidroside ameliorates insulin resistance through activation of a mitochondria‐associated AMPK/PI3K/A kt/GSK 3β pathway

T Zheng, X Yang, D Wu, S Xing, F Bian… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Recent reports have suggested that salidroside could protect
cardiomyocytes from oxidative injury and stimulate glucose uptake in skeletal muscle cells …

Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3

Y Li, X Wei, SL Liu, Y Zhao, S Jin… - Phytotherapy …, 2021 - Wiley Online Library
To investigate the effects and the underlying mechanisms of salidroside on diabetic
cardiomyopathy, diabetes was induced in mice by a long‐term high‐fat diet and a low‐dose …

[HTML][HTML] Antidiabetic effect of salvianolic acid A on diabetic animal models via AMPK activation and mitochondrial regulation

G Qiang, X Yang, L Shi, H Zhang, B Chen… - Cellular Physiology and …, 2015 - karger.com
Background/Aims: Diabetes mellitus (DM) characterized by hyperglycemia contributes to
macrovascular and microvascular complications. Salvianolic acid A (SalA) is a polyphenolic …

Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase

HB Li, Y Ge, XX Zheng, L Zhang - European journal of pharmacology, 2008 - Elsevier
In the present study, we reported the metabolic effects of salidroside, one of the active
components of Rhodiola Rosea, on skeletal muscle cells. Salidroside dose-dependently …

[HTML][HTML] Salvianolic acid B ameliorates hyperglycemia and dyslipidemia in db/db mice through the AMPK pathway

MQ Huang, CJ Zhou, YP Zhang, XQ Zhang… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Salvianolic acid B (Sal B), a major polyphenolic compound of Salvia
miltiorrhiza Bunge, has been shown to possess potential antidiabetic activities. However, the …

Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis)

SE Mazibuko, CJF Muller, E Joubert, D De Beer… - Phytomedicine, 2013 - Elsevier
Increased levels of free fatty acids (FFAs), specifically saturated free fatty acids such as
palmitate are associated with insulin resistance of muscle, fat and liver. Skeletal muscle …

Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway

H Zhong, H Xin, LX Wu, YZ Zhu - Journal of pharmacological sciences, 2010 - Elsevier
In the present study, we investigated cardioprotective effects of salidroside, isolated from
Rhodiola rosea L, on oxygen–glucose deprivation (OGD)-induced cardiomyocyte death and …

Salidroside-can it be a multifunctional drug?

SKJ Magani, SD Mupparthi, BP Gollapalli… - Current Drug …, 2020 - ingentaconnect.com
Background: Salidroside is a glucoside of tyrosol found mostly in the roots of Rhodiola spp. It
exhibits diverse biological and pharmacological properties. In the last decade, enormous …

Salsalate (salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK-β1

BK Smith, RJ Ford, EM Desjardins, AE Green… - Diabetes, 2016 - Am Diabetes Assoc
Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes
(T2D) and reduces nonalcoholic fatty liver disease (NAFLD) in animal models; however, the …

[HTML][HTML] Salidroside, a natural antioxidant, improves β-cell survival and function via activating AMPK pathway

L Ju, X Wen, C Wang, Y Wei, Y Peng, Y Ding… - Frontiers in …, 2017 - frontiersin.org
Aim: The enhanced oxidative stress contributes to progression of type 2 diabetes mellitus
(T2DM) and induces β-cell failure. Salidroside is a natural antioxidant extracted from …