Many behavioral and psychological symptoms of dementia (BPSD) share similarities in
executive functioning and communication deficits with those described in several …

The neuroimmune system represents a dense network of biochemical signals associated
with neurotransmitters, neuropeptides, neurohormones, cytokines, chemokines, and growth …

Background Histamine is commonly acknowledged as an inflammatory mediator in
peripheral tissues, leaving its role in brain immune responses scarcely studied. Therefore …

Neuroimmune dysregulation is a common phenomenon in different forms of central nervous
system (CNS) disorders. Cross‐links between central and peripheral immune mechanisms …

The biogenic amine, histamine, has been shown to critically modulate inflammatory
processes as well as the properties of neurons and synapses in the brain, and is also …

Several hypotheses have been raised about the dual role of histamine in neurological
disorders, and evidences have shown its crucial involvement in the modulation of microglia …

Background Histamine is an amine widely known as a peripheral inflammatory mediator and
as a neurotransmitter in the central nervous system. Recently, it has been suggested that …

The potential contributions of the brain histaminergic system in neurodegenerative diseases,
and the possiblity of histamine-targeting treatments is attracting considerable interests. The …

The histaminergic system (HS) has a critical role in cognition, sleep and other behaviors.
Although not well studied in autism spectrum disorder (ASD), the HS is implicated in many …

Histamine H3 receptor antagonists enhance cognition in preclinical models and have been
proposed as novel therapeutics for cognitive disorders, in particular Alzheimer's disease …