Biochemical confirmation of a diagnosis of hypercortisolism (Cushing syndrome) is vital to
direct further investigations, especially given the overlap with non-autonomous conditions …

Determination of cortisol levels in the urine (24 hours urine free cortisol), saliva (late-night),
or serum (total cortisol after dexamethasone suppression) is recommended to screen for …

Many Endocrinologists believe that a single determination of eucortisolism or a single
demonstration of appropriate suppression to dexamethasone excluded Cushing's …

BACKGROUND Hypercortisolism occurs only rarely but is often considered a possible
diagnosis in patients who have the common findings of obesity, hypertension, or diabetes …

The diagnosis of Cushing's syndrome is challenging to endocrinologists as patients often
present with an insidious history, together with subtle external clinical features. Moreover …

Cushing's syndrome results from chronic inappropriate exposure to excessive glucocorticoid
concentrations. Low-dose dexamethasone suppression, late-night salivary cortisol, and 24-h …

Measurement of 24-h urine-free cortisol is frequently employed as a first-line screening and
disease-monitoring test in Cushing's syndrome (CS). The quest for 'cortisol specificity'has …

Diagnosis and Differential Diagnosis of Cushing’s Syndrome | New England Journal of Medicine
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Endogenous Cushing's syndrome (CS) is a rare disease, and usually characterized by
hypertension, diabetes, obesity, osteoporosis, facial rounding, dorsocervical fat pad, thin …

The diagnosis and differential diagnosis of Cushing's syndrome are challenging clinical
problems in endocrinology. Traditional approaches have failed to provide adequate …