Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …

Disruption of cellular functions with aging-induced accumulation of neuronal stressors
causes cell death which is a common feature of neurodegenerative diseases. Studies in a …

Cell death is a key feature of neurological diseases, including stroke and neurodegenerative
disorders. Studies in a variety of ischemic/hypoxic mouse models demonstrate that poly …

Neurodegeneration is a salient feature of chronic refractory brain disorders like Alzheimer's,
Parkinson's, Huntington's, amyotropic lateral sclerosis and acute conditions like cerebral …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is a first responder that recognizes DNA
damage and facilitates its repair. Neurodegenerative diseases, characterized by progressive …

Abstract Poly-ADP-ribose polymerase-1 (PARP-1)'s multiple roles in the cell span from
maintaining life to inducing death. The processes PARP-1 is involved in include, but are not …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein activated by DNA damage.
PARP-1 activation is associated in DNA repair, cell death and inflammation. Since oxidative …

The defining feature of Parkinson's disease is a progressive and selective demise of
dopaminergic neurons. A recent report on Parkinson's disease animal model demonstrates …

Abstract Poly (ADP-ribose) polymerases (PARPs) constitute a family of enzymes associated
with divergent cellular processes that are not limited to DNA repair, chromatin organization …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in multiple neurologic
diseases by mediating caspase-independent cell death, which has recently been …