Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …

The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …

For more than two decades, researchers have attempted to find a way to use the skin as a
portal of entry for drugs in order to overcome problems associated with traditional modes of …

Introduction Investigating the transportation of a drug molecule through various layers of skin
and determining the amount of drug retention in skin layers is of prime importance in …

The skin is the largest organ of the body, covering about 1.7 m 2 and comprising
approximately 10% of the total body mass of an average person. The primary function of the …

As epidermal keratinocytes differentiate, they synthesize lipids, much of which are packaged
into small organelles called lamellar granules. Acetate from the circulation serves as the …

The skin has been employed as a delivery route for localized as well as systemic delivery of
drugs. However, the Stratum corneum (SC) of the skin act as a main barrier for the …

Drug penetration and permeation through the skin are greatly influenced by the structural
properties of the skin and the physicochemical properties of the drug. As such, penetration …

Considerable advances in our understanding of the mechanisms by which drugs permeate
the skin barrier have been made over the past 60 years. The key publications, which have …

The development of topical drug delivery systems has recently gained significant interest
due to the ease of administration and lesser risks of systemic toxicity. The development of …