Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states

A Ally, I Powell, MM Ally, K Chaitoff, SM Nauli - Nitric Oxide, 2020 - Elsevier
This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on
the central nervous system, particularly on brain regions such as the ventrolateral medulla …

Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems

Y Wang, J Golledge - Current neurovascular research, 2013 - ingentaconnect.com
Nitric oxide, derived from nitric oxide synthase (NOS), plays an important role in regulating
sympathetic nerve activity. Neuronal NOS (nNOS) is expressed throughout the central and …

[HTML][HTML] Neuronal nitric oxide synthase in vascular physiology and diseases

ED Costa, BA Rezende, SF Cortes… - Frontiers in physiology, 2016 - frontiersin.org
The family of nitric oxide synthases (NOS) has significant importance in various
physiological mechanisms and is also involved in many pathological processes. Three NOS …

Post-translational regulation of neuronal nitric oxide synthase: implications for sympathoexcitatory states

NM Sharma, KP Patel - Expert opinion on therapeutic targets, 2017 - Taylor & Francis
Introduction: Nitric oxide (NO) synthesized via neuronal nitric oxide synthase (nNOS) plays a
significant role in regulation/modulation of autonomic control of circulation. Various …

[HTML][HTML] Neuronal nitric oxide synthase and human vascular regulation

N Melikian, MD Seddon, B Casadei… - Trends in cardiovascular …, 2009 - Elsevier
Vascular blood flow and its distribution among different vascular beds are regulated by
changes in microvascular tone. Nitric oxide (NO) plays a key role in the local paracrine …

[HTML][HTML] Neuronal nitric oxide synthase in hypertension–an update

YH Zhang - Clinical hypertension, 2016 - Springer
Hypertension is a prevalent condition worldwide and is the key risk factor for fatal
cardiovascular complications, such as stroke, sudden cardiac death and heart failure …

The physiology and pathophysiology of nitric oxide in the brain

FX Guix, I Uribesalgo, M Coma, FJ Munoz - Progress in neurobiology, 2005 - Elsevier
Nitric oxide (NO) is a molecule with pleiotropic effects in different tissues. NO is synthesized
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …

Molecular mechanisms of neuronal nitric oxide synthase in cardiac function and pathophysiology

YH Zhang, CZ Jin, JH Jang… - The Journal of physiology, 2014 - Wiley Online Library
Neuronal nitric oxide synthase (nNOS or NOS1) is the major endogenous source of
myocardial nitric oxide (NO), which facilitates cardiac relaxation and modulates contraction …

Physiological and pathophysiological roles of nitric oxide in the central nervous system

C Szabó - Brain research bulletin, 1996 - Elsevier
Nitric oxide (NO) is produced by three distinct isoforms of nitric oxide synthases in the central
nervous system. Here, the roles of nitric oxide in the central nervous system are reviewed …

Nitric oxide synthases in the cardiovascular system

U Förstermann, JS Pollock, M Nakane - Trends in Cardiovascular Medicine, 1993 - Elsevier
The endothelium-derived relaxing factor that mediates the endothelium-dependent
vasodilatation first observed in 1980 has been identified as nitric oxide (NO). In addition to …