The diffuse neuroendocrine system consists of specialised endocrine cells and peptidergic
nerves and is present in all organs of the body. Substance P (SP) is secreted by nerves and …

The neuropeptide substance P modulates the activities of a number of different leukocytes
that characterize both acute and delayed inflammatory responses. Substance P may play a …

Tachykinins such as substance P (SP) may be involved in the pathogenesis of inflammatory
airway diseases such as asthma. This study investigated the presence of SP and its receptor …

Communication between nerves and immune and inflammatory cells of the small and large
intestine plays a major role in the modulation of several intestinal functions, including …

This article provides a brief overview of the history of substance P from its discovery in the
1930s to the present day. The development of substance P receptor agonists and …

The peptide substance P (SP) shows a widespread distribution in both the central and
peripheral nervous systems, but it is also present in cells not belonging to the nervous …

Although substance P (SP) has been implicated as a mediator of neurogenic inflammation in
the small intestine, little information is available regarding the role of SP in the pathogenesis …

Substance P (SP) participates in acute intestinal inflammation via binding to the G-protein-
coupled neurokinin-1 receptor (NK-1R) and release of proinflammatory cytokines from …

Substance P (SP) via its neurokinin-1 receptor (NK-1R) regulates several gastrointestinal
functions. We previously reported that NK-1R-mediated chloride secretion in the colon …

Substance P (SP) participates in acute intestinal inflammation via binding to the G-protein-
coupled neurokinin-1 receptor (NK-1R) and release of nuclear factor κ B (NF-κB)-driven …