Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery

S Gaines, C Shao, N Hyman… - Journal of British …, 2018 - academic.oup.com
Background The pathogenesis of colorectal cancer recurrence after a curative resection
remains poorly understood. A yet-to-be accounted for variable is the composition and …

Role of the intestinal microbiome in colorectal cancer surgery outcomes

L Lauka, E Reitano, MC Carra, F Gaiani… - World journal of surgical …, 2019 - Springer
Objectives Growing evidence supports the role of the intestinal microbiome in the
carcinogenesis of colorectal cancers, but its impact on colorectal cancer surgery outcomes is …

Novel insight into the role of microbiota in colorectal surgery

R Bachmann, D Leonard, N Delzenne, A Kartheuser… - Gut, 2017 - gut.bmj.com
Recent literature undeniably supports the idea that the microbiota has a strong influence on
the healing process of an intestinal anastomosis. Understanding the mechanisms by which …

Intestinal microbiota in colorectal cancer surgery

I Koliarakis, E Athanasakis, M Sgantzos… - Cancers, 2020 - mdpi.com
Simple Summary The microbial communities of the intestine exist in a delicate balance with
the human. Colorectal cancer is one of the most common gastrointestinal malignancies, and …

Mucus microbiome of anastomotic tissue during surgery has predictive value for colorectal anastomotic leakage

JB van Praagh, MC de Goffau, IS Bakker… - Annals of …, 2019 - journals.lww.com
Objective: The aim of the present study is to investigate the association of gut microbiota,
depending on treatment method, with the development of colorectal anastomotic leakage …

Postoperative changes of the microbiome: are surgical complications related to the gut flora? A systematic review

AK Lederer, P Pisarski, L Kousoulas, S Fichtner-Feigl… - BMC surgery, 2017 - Springer
Background The purpose of this review was to identify the relationship between the gut
microbiome and the development of postoperative complications like anastomotic leakage …

Intestinal anastomotic injury alters spatially defined microbiome composition and function

BD Shogan, DP Smith, S Christley, JA Gilbert… - Microbiome, 2014 - Springer
Background When diseased intestine (ie, from colon cancer, diverticulitis) requires
resection, its reconnection (termed anastomosis) can be complicated by non-healing of the …

Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines

R Hajjar, E Gonzalez, G Fragoso, M Oliero, AA Alaoui… - Gut, 2023 - gut.bmj.com
Objective Colorectal cancer (CRC) is the third most diagnosed cancer, and requires surgical
resection and reconnection, or anastomosis, of the remaining bowel to re-establish intestinal …

The gut microbiota and colorectal surgery outcomes: facts or hype? A narrative review

A Agnes, C Puccioni, D D'Ugo, A Gasbarrini, A Biondi… - BMC surgery, 2021 - Springer
Background The gut microbiota (GM) has been proposed as one of the main determinants of
colorectal surgery complications and theorized as the “missing factor” that could explain still …

Intestinal microbiota and anastomotic leakage of stapled colorectal anastomoses: a pilot study

JB van Praagh, MC de Goffau, IS Bakker… - Surgical …, 2016 - Springer
Background Anastomotic leakage (AL) after colorectal surgery is a severe complication,
resulting in morbidity, reinterventions, prolonged hospital stay and, in some cases, death …