The historical breakthrough of glucocorticoids as a pharmacological agent can be traced
back to 1929. At the time, Dr. Philip S. Hench developed the concept that steroids could …

Glucocorticoids represent the most important and frequently used class of drugs in the
management of many inflammatory and immunologic conditions. Beside these beneficial …

A growing area of research in pharmacology and toxicology is concerned with the role of
adrenal glucocorticosteroids (predominantly corticosterone in rats and mice, and cortisol in …

Glucocorticoids are amongst the most potent immunosuppressant drugs available and are
widely used in many inflammatory and autoimmune conditions such as asthma and systemic …

Over fifty years have now elapsed since glucocorticoids were first employed as anti-
inflammatory drugs in the clinic. At that time, Dr Philip Hench and his colleagues at the Mayo …

Glucocorticoids are the most effective anti-inflammatory agents known. However, the use of
these powerful molecules is plagued by a host of serious, sometimes life-threatening side …

Activation of the hypothalamus-pituitary-adrenal (HPA) axis by a variety of stressors results
in the secretion by the adrenal cortex of glucocorticoids. The primary physiological function …

Glucocorticoids (GCs) have been the cornerstone of treating dozens of inflammatory
conditions for more than seven decades. GC toxicity is ubiquitous in both clinical trials and …

Corticosteroids have been a mainstay of treatment employed by rheumatologists since the
Nobel Prize–winning discovery of cortisone in 1950 by Drs Hench, Kendall, and Reichstein …

Corticosteroids are a class of steroid hormones released by the adrenal cortex, which
includes glucocorticoids and mineralocorticoids. 1 However, the term “corticosteroids” is …