The developmental origins of memory T cells remain incompletely understood. During the
expansion phase of acute viral infection, we identified a distinct subset of virus-specific …

Memory CD8+ T-cell development is defined by the expression of a specific set of memory
signature genes. Despite recent progress, many components of the transcriptional control of …

Understanding the regulation of the CD8+ T-cell response and how protective memory cells
are generated has been intensely studied. It is now appreciated that a naive CD8+ T cell …

T cell memory relies on the generation of antigen-specific progenitors with stem-like
properties. However, the identity of these progenitors has remained unclear, precluding a …

Chronic infections promote the terminal differentiation (or" exhaustion") of T cells and are
thought to preclude the formation of memory T cells. In contrast, we discovered a small …

Early after priming, effector CD8 T cells are distinguished into memory precursor and short-
lived effector cell subsets (MPECs and SLECs). Here, we delineated a distinct in vivo …

In response to infection or effective vaccination, naive antigen‐specific CD8+ T cells
undergo a dramatic highly orchestrated activation process. Initial encounter with an …

Memory CD4+ T cells play a pivotal role in mediating long-term protective immunity,
positioning them as an important target in vaccine development. However, multiple …

The development of immune memory mediated by T lymphocytes is central to durable, long‐
lasting protective immunity. A key issue in the field is how to direct the generation and …

There are currently two models for the generation of memory T cells: 1) memory T cells arise
directly from activated effector T cells that have reverted to the resting state via an unknown …