Chronic low back pain is a common condition, with high societal costs and often ineffectual
treatments. Communication between macrophages/monocytes (MØ) and sensory neurons …

Neuropathic pain resulting from damage to or dysfunction of peripheral nerves is not well
understood and difficult to treat. Although CNS hyperexcitability is a critical component …

Pain is the major debilitating symptom of osteoarthritis (OA), which is difficult to treat. In OA
patients joint tissue damage only poorly associates with pain, indicating other mechanisms …

Pain is a persistent symptom of Rheumatoid Arthritis, and the K/BxN serum transfer model
recapitulates both association and dissociation between pain and joint inflammation in RA …

Mice lacking the chemokine receptor chemotactic cytokine receptor 2 (CCR2) have a
marked attenuation of monocyte recruitment in response to various inflammatory stimuli and …

Objective The role of inflammation in structural and symptomatic osteoarthritis (OA) remains
unclear. One key mediator of inflammation is the chemokine CCL2, primarily responsible for …

Chemokines are chemotactic cytokines whose involvement in nociceptive processing is
being increasingly recognized. Based on the previous description of the involvement of CC …

Background Pain is reported as the leading cause of disability in the common forms of
inflammatory arthritis conditions. Acting as a key player in nociceptive processing …

Background: The CCR2/CCL2 system has been identified as a regulator in the
pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia …

Millions of people suffer from arthritis worldwide, consistently struggling with daily activities
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …