[HTML][HTML] Obesity, type 2 diabetes, and cancer: the insulin and IGF connection

DH Cohen, D LeRoith - Endocrine-related cancer, 2012 - erc.bioscientifica.com
Epidemiological studies suggest a positive association between obesity and type 2 diabetes
mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance …

Insulin, insulin resistance, obesity, and cancer

EJ Gallagher, D LeRoith - Current diabetes reports, 2010 - Springer
Epidemiologic studies have proposed a link between obesity, type 2 diabetes, and cancer.
The pathophysiologic mechanisms involved in the development of type 2 diabetes, namely …

[HTML][HTML] Obesity, type 2 diabetes, and cancer risk

T Scully, A Ettela, D LeRoith, EJ Gallagher - Frontiers in oncology, 2021 - frontiersin.org
Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …

[HTML][HTML] Epidemiology and molecular mechanisms tying obesity, diabetes, and the metabolic syndrome with cancer

EJ Gallagher, D LeRoith - Diabetes care, 2013 - ncbi.nlm.nih.gov
It is well recognized that the world is witnessing an epidemic of obesity and type 2 diabetes
(T2D). Numerous studies have shown that both obesity and T2D are associated with an …

Obesity and cancer risk: the role of the insulin–IGF axis

AG Renehan, J Frystyk, A Flyvbjerg - Trends in Endocrinology & Metabolism, 2006 - cell.com
Accumulating epidemiological evidence shows that being either overweight or obese, in
other words having excess body weight (EBW), is associated with an increased risk of …

Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence

D LeRoith, R Novosyadlyy, EJ Gallagher… - Experimental and …, 2008 - thieme-connect.com
Both obesity and Type 2 diabetes are independently associated with an increased risk of
developing cancer and an increased mortality. The etiology is yet to be determined but …

Mechanistic links between obesity, insulin, and cancer

RJ Perry, GI Shulman - Trends in cancer, 2020 - cell.com
Obesity and type 2 diabetes (T2D) increase the prevalence and worsen the prognosis of
more than a dozen tumor types; however, the mechanism for this association remains hotly …

Insulin and cancer

DB Boyd - Integrative cancer therapies, 2003 - journals.sagepub.com
Obesity has recently been linked to mortality from the majority of cancers. The insulin/insulin-
like growth factor (IGF) system may partly explain this effect. The metabolic syndrome …

A twenty‐first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin‐like growth factors

RL Westley, FEB May - International journal of endocrinology, 2013 - Wiley Online Library
Obesity has reached epidemic proportions in the developed world. The progression from
obesity to diabetes mellitus type 2, via metabolic syndrome, is recognised, and the …

Obesity and diabetes: the increased risk of cancer and cancer-related mortality

EJ Gallagher, D LeRoith - Physiological reviews, 2015 - journals.physiology.org
Obesity and type 2 diabetes are becoming increasingly prevalent worldwide, and both are
associated with an increased incidence and mortality from many cancers. The metabolic …