Small RNA as global regulator of carbon catabolite repression in Pseudomonas aeruginosa

E Sonnleitner, L Abdou, D Haas - Proceedings of the …, 2009 - National Acad Sciences
In the metabolically versatile bacterium Pseudomonas aeruginosa, the RNA-binding protein
Crc is involved in catabolite repression of a range of degradative genes, such as amiE …

Two small RNAs, CrcY and CrcZ, act in concert to sequester the Crc global regulator in Pseudomonas putida, modulating catabolite repression

R Moreno, P Fonseca, F Rojo - Molecular microbiology, 2012 - Wiley Online Library
The Crc protein is a translational repressor that recognizes a specific target at some mRNAs,
controlling catabolite repression and co‐ordinating carbon metabolism in pseudomonads. In …

Novel Targets of the CbrAB/Crc Carbon Catabolite Control System Revealed by Transcript Abundance in Pseudomonas aeruginosa

E Sonnleitner, M Valentini, N Wenner, FZ Haichar… - PloS one, 2012 - journals.plos.org
The opportunistic human pathogen Pseudomonas aeruginosa is able to utilize a wide range
of carbon and nitrogen compounds, allowing it to grow in vastly different environments. The …

Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression

E Sonnleitner, U Bläsi - PLoS Genetics, 2014 - journals.plos.org
Carbon Catabolite repression (CCR) allows a fast adaptation of Bacteria to changing
nutrient supplies. The Pseudomonas aeruginosa (PAO1) catabolite repression control …

Hierarchical management of carbon sources is regulated similarly by the CbrA/B systems in Pseudomonas aeruginosa and Pseudomonas putida

M Valentini, SM García-Mauriño… - …, 2014 - microbiologyresearch.org
The CbrA/B system in pseudomonads is involved in the utilization of carbon sources and
carbon catabolite repression (CCR) through the activation of the small RNAs crcZ in …

Small RNAs as regulators of primary and secondary metabolism in Pseudomonas species

E Sonnleitner, D Haas - Applied microbiology and biotechnology, 2011 - Springer
Small RNAs (sRNAs) exert important functions in pseudomonads. Classical sRNAs
comprise the 4.5 S, 6S, 10Sa and 10Sb RNAs, which are known in enteric bacteria as part of …

Carbon catabolite repression in bacteria: choice of the carbon source and autoregulatory limitation of sugar utilization

R Brückner, F Titgemeyer - FEMS microbiology letters, 2002 - academic.oup.com
Carbon catabolite repression (CCR) in bacteria is generally regarded as a regulatory
mechanism to ensure sequential utilization of carbohydrates. Selection of the carbon …

The Pseudomonas putida Crc global regulator is an RNA binding protein that inhibits translation of the AlkS transcriptional regulator

R Moreno, A Ruiz‐Manzano, L Yuste… - Molecular …, 2007 - Wiley Online Library
The Crc protein is a global regulator that controls the hierarchical assimilation of carbon
sources in Pseudomonads by inhibiting expression of several catabolic pathways. Crc does …

The Target for the Pseudomonas putida Crc Global Regulator in the Benzoate Degradation Pathway Is the BenR Transcriptional Regulator

R Moreno, F Rojo - Journal of bacteriology, 2008 - Am Soc Microbiol
Crc protein is a global regulator involved in catabolite repression control of several
pathways for the assimilation of carbon sources in pseudomonads when other preferred …

The CbrA–CbrB two‐component regulatory system controls the utilization of multiple carbon and nitrogen sources in Pseudomonas aeruginosa

T Nishijyo, D Haas, Y Itoh - Molecular microbiology, 2001 - Wiley Online Library
A novel two‐component system, CbrA–CbrB, was discovered in Pseudomonas aeruginosa;
cbrA and cbrB mutants of strain PAO were found to be unable to use several amino acids …