The sensation of cold or heat depends on the activation of specific nerve endings in the skin.
This involves heat‐and cold‐sensitive excitatory transient receptor potential (TRP) channels …

The TREK‐1 channel is a temperature‐sensitive, osmosensitive and mechano‐gated K+
channel with a regulation by Gs and Gq coupled receptors. This paper demonstrates that …

Two-pore domain background K+ channels (K2p or KCNK) produce hyperpolarizing
currents that control cell membrane polarity and neuronal excitability throughout the nervous …

Peripheral and central thermoreceptors are involved in sensing ambient and body
temperature, respectively. Specialized cold and warm receptors are present in dorsal root …

Controlling body temperature is a matter of life or death for most animals, and in mammals
the complex thermoregulatory system is comprised of thermoreceptors, thermosensors, and …

We feel a wide range of temperatures spanning from coldness to heat. Within this range,
temperatures over about 43 C and below about 15 C evoke not only a thermal sensation, but …

Cold temperature can evoke a wide spectrum of perceptual sensations that range from
freshness to unpleasant cold or overt pain. In mammals, the detection of cold temperature is …

Molecular determinants of threshold differences among cold thermoreceptors are unknown.
Here we show that such differences correlate with the relative expression of I KD, a current …

TRPA1 functions as an excitatory ionotropic receptor in sensory neurons. It was originally
described as a noxious cold-activated channel, but its cold sensitivity has been disputed in …

Cooling is sensed by peripheral thermoreceptors, the main transduction mechanism of
which is probably a cold-and menthol-activated ion channel, transient receptor potential …