BACKGROUND Androgens, FSH, anti-Müllerian hormone (AMH) and estradiol (E2) are
essential in human ovarian folliculogenesis. However, the interactions between these four …

This review exposes the follicular abnormalities responsible for anovulation in polycystic
ovary syndrome (PCOS). The putative pathophysiological explanations involve the principal …

Background. Although chronic hyperandrogenism, a typical feature of polycystic ovary
syndrome, is often associated with disturbed reproductive performance, androgens have …

STUDY QUESTION What prevents the fall in anti-Müllerian hormone (AMH) levels in
polycystic ovary syndrome (PCOS) and what are the consequences of this for follicle …

Context: Recent evidence indicates that the increase in follicle numbers seen in polycystic
ovary syndrome occurs early in folliculogenesis, with androgens being a likely causative …

BACKGROUND Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory
infertility and menstrual cycle abnormalities, but the factors responsible for failure to select a …

OBJECTIVE: To determine that anti-Müllerian hormone (AMH) has been shown to inhibits
E2 production in rodents and in luteinized granulosa cells (GC). We determined whether this …

Purpose Anti Müllerian Hormone (AMH) has a negative and inhibitory role in many functions
of human granulosa-lutein cells (hGCs) including notoriously the reduction of the aromatase …

STUDY QUESTION Is intrinsic dysregulation of granulosa cells (GC) and consequent
increases in the per-follicle production of anti-Müllerian hormone (AMH), correlated with the …

The cardinal features of polycystic ovary syndrome (PCOS) are hyperandrogenism and
oligoanovulation. The increase in ovarian androgen production is a fundamental …