Enzymatic synthesis of psilocybin
J Fricke, F Blei, D Hoffmeister - … Chemie International Edition, 2017 - Wiley Online Library
Psilocybin is the psychotropic tryptamine‐derived natural product of Psilocybe carpophores,
the so‐called “magic mushrooms”. Although its structure has been known for 60 years, the …
the so‐called “magic mushrooms”. Although its structure has been known for 60 years, the …
[HTML][HTML] Metabolic engineering of Saccharomyces cerevisiae for the de novo production of psilocybin and related tryptamine derivatives
N Milne, P Thomsen, N Knudsen, P Rubaszka… - Metabolic …, 2020 - Elsevier
Psilocybin is a tryptamine-derived psychoactive alkaloid found mainly in the fungal genus
Psilocybe, among others, and is the active ingredient in so-called “magic mushrooms” …
Psilocybe, among others, and is the active ingredient in so-called “magic mushrooms” …
Injury‐Triggered Blueing Reactions of Psilocybe “Magic” Mushrooms
C Lenz, J Wick, D Braga, M García‐Altares… - Angewandte …, 2020 - Wiley Online Library
Upon injury, psychotropic psilocybin‐producing mushrooms instantly develop an intense
blue color, the chemical basis and mode of formation of which has remained elusive. We …
blue color, the chemical basis and mode of formation of which has remained elusive. We …
Concise large-scale synthesis of psilocin and psilocybin, principal hallucinogenic constituents of “magic mushroom”
The concise large-scale syntheses of psilocin (1) and psilocybin (2), the principal
hallucinogenic constituents of “magic mushroom”, were achieved without chromatographic …
hallucinogenic constituents of “magic mushroom”, were achieved without chromatographic …
Simultaneous production of psilocybin and a cocktail of β‐carboline monoamine oxidase inhibitors in “magic” mushrooms
F Blei, S Dörner, J Fricke, F Baldeweg… - … A European Journal, 2020 - Wiley Online Library
The psychotropic effects of Psilocybe “magic” mushrooms are caused by the l‐tryptophan‐
derived alkaloid psilocybin. Despite their significance, the secondary metabolome of these …
derived alkaloid psilocybin. Despite their significance, the secondary metabolome of these …
Direct phosphorylation of psilocin enables optimized cGMP kilogram-scale manufacture of psilocybin
A second-generation kilogram-scale synthesis of the psychedelic tryptamine psilocybin has
been developed. The synthesis was designed to address several challenges first …
been developed. The synthesis was designed to address several challenges first …
In vivo production of psilocybin in E. coli
Psilocybin, the prodrug of the psychoactive molecule psilocin, has demonstrated promising
results in clinical trials for the treatment of addiction, depression, and post-traumatic stress …
results in clinical trials for the treatment of addiction, depression, and post-traumatic stress …
A concise synthesis of berkelic acid inspired by combining the natural products spicifernin and pulvilloric acid
CF Bender, FK Yoshimoto, CL Paradise… - Journal of the …, 2009 - ACS Publications
We describe a concise synthesis of the structurally novel fungal extremophile metabolite
berkelic acid, an effort leading to an unambiguous assignment of C22 stereochemistry. Our …
berkelic acid, an effort leading to an unambiguous assignment of C22 stereochemistry. Our …
Pictet–Spengler reaction-based biosynthetic machinery in fungi
The Pictet–Spengler (PS) reaction constructs plant alkaloids such as morphine and
camptothecin, but it has not yet been noticed in the fungal kingdom. Here, a silent fungal …
camptothecin, but it has not yet been noticed in the fungal kingdom. Here, a silent fungal …
The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria
U Metzger, C Schall, G Zocher… - Proceedings of the …, 2009 - National Acad Sciences
Ergot alkaloids are toxins and important pharmaceuticals that are produced
biotechnologically on an industrial scale. The first committed step of ergot alkaloid …
biotechnologically on an industrial scale. The first committed step of ergot alkaloid …