Psilocybin is the psychotropic tryptamine‐derived natural product of Psilocybe carpophores,
the so‐called “magic mushrooms”. Although its structure has been known for 60 years, the …

Psilocybin is a tryptamine-derived psychoactive alkaloid found mainly in the fungal genus
Psilocybe, among others, and is the active ingredient in so-called “magic mushrooms” …

Upon injury, psychotropic psilocybin‐producing mushrooms instantly develop an intense
blue color, the chemical basis and mode of formation of which has remained elusive. We …

The concise large-scale syntheses of psilocin (1) and psilocybin (2), the principal
hallucinogenic constituents of “magic mushroom”, were achieved without chromatographic …

The psychotropic effects of Psilocybe “magic” mushrooms are caused by the l‐tryptophan‐
derived alkaloid psilocybin. Despite their significance, the secondary metabolome of these …

A second-generation kilogram-scale synthesis of the psychedelic tryptamine psilocybin has
been developed. The synthesis was designed to address several challenges first …

Psilocybin, the prodrug of the psychoactive molecule psilocin, has demonstrated promising
results in clinical trials for the treatment of addiction, depression, and post-traumatic stress …

We describe a concise synthesis of the structurally novel fungal extremophile metabolite
berkelic acid, an effort leading to an unambiguous assignment of C22 stereochemistry. Our …

The Pictet–Spengler (PS) reaction constructs plant alkaloids such as morphine and
camptothecin, but it has not yet been noticed in the fungal kingdom. Here, a silent fungal …

Ergot alkaloids are toxins and important pharmaceuticals that are produced
biotechnologically on an industrial scale. The first committed step of ergot alkaloid …