Monoterpenoid indole alkaloid dimers from the Melodinus axillaris induce G2/M phase arrest and apoptosis via p38 MAPK activation in HCT116 cells

K Du, X Li, C Zheng, L Lai, M Shen, Y Wang… - Bioorganic Chemistry, 2023 - Elsevier
Four monoterpenoid indole alkaloid dimers (MIADs), axidimins AD (1–4), which possesses
unprecedented apidosperma-aspidosperma-type skeletons, along with twelve known MIAs …

A novel monoterpenoid indole alkaloid with anticancer activity from Melodinus khasianus

J Zhou, JH Feng, L Fang - Bioorganic & medicinal chemistry letters, 2017 - Elsevier
A novel monoterpenoid indole alkaloid with unprecedented 6/5/6/4/6 fused rings,
khasuanine A (1), was isolated from the roots of Melodinus khasianus. The structure was …

Melosuavine I, an apoptosis-inducing bisindole alkaloid from Melodinus suaveolens

ZY Fang, YD Ren, SY Du, M Zhang, YS Wang, L Fang… - Fitoterapia, 2019 - Elsevier
A new bisindole alkaloid, melosuavine I (1) possessing an aspidosperma-aspidosperma
dimeric skeleton, was isolated from the leaves of Melodinus suaveolens. The structure with …

Melognine, a novel monoterpenoid indole alkaloid from Melodinus fusiformis that induce apoptosis in BT549 cells

J Zhou, SY Du, ZY Fang, JH Feng - Natural Product Research, 2021 - Taylor & Francis
A novel monoterpenoid indole alkaloid, melognine (1) possessing an unprecedented
skeleton with a 6/6/5/5/6/6 hexatomic rearranged ring system was isolated from the stems of …

Isovincathicine from Catharanthus roseus induces apoptosis in A549 cells

M Hiroki, A Abulikemu, C Totsuka, Y Hirasawa… - Journal of Natural …, 2024 - Springer
A dimeric indole alkaloid, isovincathicine consisting of an aspidosperma type and modified
iboga with C-7–C-20 connection type skeletons was first isolated from Catharanthus roseus …

The amide derivative of anticopalic acid induces non-apoptotic cell death in triple-negative breast cancer cells by inhibiting FAK activation

P Chawengrum, N Luepongpatthana, S Thongnest… - Scientific Reports, 2023 - nature.com
Anticopalic acid (ACP), a labdane type diterpenoid obtained from Kaempferia elegans
rhizomes, together with 21 semi-synthetic derivatives, were evaluated for their cancer …

Promising Anticancer Activities of Alismatis rhizome and Its Triterpenes via p38 and PI3K/Akt/mTOR Signaling Pathways

E Jang, JH Lee - Nutrients, 2021 - mdpi.com
The flowering plant genus Alisma, which belongs to the family Alismataceae, comprises 11
species, including Alisma orientale, Alisma canaliculatum, and Alisma plantago-aquatica …

Monoterpenoid indole alkaloids from Melodinus axillaris WT Wang exhibit anti-inflammatory activities by inhibiting the NF-κB signaling pathways

K Du, Y Liang, Z Song, C Zheng, L Lai, K Zong… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Melodinus axillaris WT Wang has been widely used as an
important medicine in China. In the folk of China, its whole plant has been used for fractures …

[HTML][HTML] Alisol B 23-acetate induces autophagic-dependent apoptosis in human colon cancer cells via ROS generation and JNK activation

Y Zhao, ETS Li, M Wang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Alisol B 23-acetate (AB23A), a natural triterpenoid from the rhizome of Alisma
orientale, a Chinese medicinal herb, has multiple physiological activities including …

Triterpenoids From Alisma Species: Phytochemistry, Structure Modification, and Bioactivities

P Wang, T Song, R Shi, M He, R Wang, J Lv… - Frontiers in …, 2020 - frontiersin.org
Plants from Alisma species belong to the genus of Alisma Linn. in Alismataceae family. The
tubers of A. orientale (Sam.) Juzep, also known as Ze Xie in Chinese and Takusha in …