During tumor development, tumor cells constantly communicate with the surrounding
microenvironment through both biochemical and biophysical cues. In particular, the tumor …

The evolution of the cancer cell into a metastatic entity is the major cause of death in patients
with cancer. Activation of the epithelial-to-mesenchymal transition (EMT) endows invasive …

Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …

Simple Summary Metastasis, the process by which cancer cells escape primary tumor site
and colonize distant organs, is responsible for most cancer-related deaths. The tumor …

During development of a novel treatment for cancer patients, the tumor microenvironment
and its interaction with the tumor cells must be considered. Aspects such as the extracellular …

Every year about 500,000 people in the United States die as a result of cancer. Among them,
90% exhibit systemic disease with metastasis. Considering this high rate of incidence and …

Genetic alterations drive tumor onset and progression. However, the cross‑talk between
tumor cells and the benign components of the surrounding stroma can also promote the …

The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the
body plan and also in the tumor invasion process. In addition, EMT also causes disruption of …

Tumor budding occurs at the invasive front of cancer; the tumor cells involved have
metastatic and stemness features, indicating a poor prognosis. Tumor budding is partly …

Tumor growth and progression are the products of complex signaling networks between
different cell types within the tumor and its surrounding stroma. In particular, established …