Lens, an avascular tissue involved in light transmission, generates an internal
microcirculatory system to promote ion and fluid circulation, thus providing nutrients to …

Both connexin 50 (Cx50) and aquaporin 0 (AQP0) have important roles in lens development
and homeostasis, and their mutations are associated with human congenital cataracts. We …

Purpose: We reported previously that aquaporin 0 (AQP0) modulates lens fiber cell gap
junction (GJ) channel function. The present study was conducted to find out whether the C …

Purpose: Connexins and aquaporins play essential roles in maintaining lens homeostasis
and transparency and there is a close physical and functional relationship between these …

Aquaporin (AQP) 1 and AQP0 water channels are expressed in lens epithelial and fiber
cells, respectively, facilitating fluid circulation for nourishing the avascular lens to maintain …

Purpose.: Lens fiber cell membranes contain aquaporin-0 (AQP0), which constitutes
approximately 50% of the total fiber cell membrane proteins and has a dual function as a …

Abstract Aquaporin 0 (AQP0) and AQP1 are expressed in the lens, each in a different cell
type, and their functional roles are not thoroughly understood. Our previous study showed …

Purpose: The objective of this study was to understand the molecular and physiologic
mechanisms behind the lens cataract differences in Aquaporin 0-knockout-Heterozygous …

Abstract Aquaporin 0 (AQP0) is a transmembrane channel that constitutes∼ 45% of the total
membrane protein of the fiber cells in mammalian lens. It is critical for lens transparency and …

The eye lens is dependent upon a network of gap junction-mediated intercellular
communication to facilitate its homeostasis and development. Three gap junction-forming …