Background Mutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-
MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing …

Context Individuals with monogenic diabetes due to inactivating glucokinase (GCK) variants
typically do not require treatment, except potentially during pregnancy. In pregnancy, fetal …

Aims/hypothesis In pregnancies where the mother has glucokinase-MODY (GCK-MODY),
fetal growth is determined by fetal genotype. When the fetus inherits a maternal pathogenic …

Background Glucokinase-maturity onset diabetes of the young (GCK-MODY) is a form of
monogenic diabetes that is caused by heterozygous inactivating mutations in GCK gene …

Heterozygous loss-of-function variants of the glucokinase (GCK) gene are responsible for a
subtype of maturity-onset diabetes of the young (MODY). GCK-MODY is characterized by a …

Glucokinase–maturity-onset diabetes of the young (GCK-MODY) is an autosomal dominant
disorder caused by heterozygous inactivating GCK gene mutations. GCK-MODY is one the …

Hyperglycemia caused by mutations in the glucokinase gene, GCK, is the most common
form of monogenic diabetes. Prenatal diagnosis is important, as it impacts on treatment. This …

Background. Gestational diabetes (GDM) due to GCK gene mutations is the most frequent
form of monogenic diabetes mellitus (DM) presenting during pregnancy. It has been …

Heterozygous mutations in GCK result in a persistent, mildly raised glucose from birth, but it
is usually diagnosed in adulthood as maturity‐onset diabetes of the young (MODY), where …

Dear Editor, Permanent neonatal diabetes mellitus (PNDM) in humans can be caused by the
homozygous nullification of glucokinase (GCK), which is a key rate-limiting enzyme in …