Possible roles of exercise and apelin against pregnancy complications

H Alizadeh Pahlavani - Frontiers in Endocrinology, 2022 - frontiersin.org
The prevalence of maternal obesity during pregnancy is associated with the risk of
gestational diabetes, preeclampsia, and cardiomyopathy. Environmental factors such as …

Exerkine apelin reverses obesity-associated placental dysfunction by accelerating mitochondrial biogenesis in mice

SA Chae, JS Son, L Zhao, Y Gao… - American Journal …, 2022 - journals.physiology.org
Maternal exercise (ME) protects against adverse effects of maternal obesity (MO) on fetal
development. As a cytokine stimulated by exercise, apelin (APN) is elevated due to ME, but …

Exercise and insulin glargine administration in mothers with diabetes during pregnancy ameliorate function of testis in offspring: Consequences on apelin-13 and its …

K Mehri, G Hamidian, S Babri, F Farajdokht, ZZ Oskuye - Life Sciences, 2024 - Elsevier
Aims Despite the evidence exhibited that diabetes during gestation (DDG) is linked with
reproductive dysfunction in offspring, the underlying cellular mechanisms involved are not …

The role of apelinergic system in metabolism and reproductive system in normal and pathological conditions: an overview

K Mehri, G Hamidian, Z Zavvari Oskuye… - Frontiers in …, 2023 - frontiersin.org
Lifestyle changes have made metabolic disorders as one of the major threats to life. Growing
evidence demonstrates that obesity and diabetes disrupt the reproductive system by …

Correlation between Apelin and Some Angiogenic Factors in the Pathogenesis of Preeclampsia: Apelin‐13 as Novel Drug for Treating Preeclampsia and Its …

RZ Hamza, AAA Diab, MH Zahra… - International Journal …, 2021 - Wiley Online Library
Preeclampsia (PE) is one of the commonest causes for maternal and fetal morbidity and
mortality. Imbalances of angiogenic factors, oxidative stress, and inflammatory response …

Apelin and apelin receptor in human placenta: Expression, signalling pathway and regulation of trophoblast JEG‑3 and BeWo cells proliferation and cell cycle

E Mlyczyńska, P Kurowska… - International …, 2020 - spandidos-publications.com
Placentation requires the production of numerous growth factors, hormones and
transcription factors. Many of them, like the adipose tissue‑derived leptin or adiponectin …

Apelin levels in normal pregnancy

A Kourtis, A Gkiomisi, M Mouzaki… - Clinical …, 2011 - Wiley Online Library
Objective Apelin is an adipokine secreted from adipose and other tissues with increased
expression in obesity, role in glucose metabolism and atherosclerosis, as well as in …

Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice

JS Son, L Zhao, Y Chen, K Chen, SA Chae… - Science …, 2020 - science.org
The obesity rate is rapidly increasing, which has been attributed to lack of exercise and
excessive energy intake. Here, we found a previously unidentified explanation, due to lack …

[PDF][PDF] Molecular communication between Apelin-13, Apelin-36, Elabela, and nitric oxide in gestational diabetes mellitus.

ZK Karagoz, S Aydin, K Ugur, A Tigli… - European Review for …, 2022 - europeanreview.org
OBJECTIVE: Gestational diabetes mellitus (GDM) is a type of diabetes that affects from 3.8%
to 6.9% of pregnancies worldwide, causing significant mortality and unfavorable obstetric …

Circulating apelin levels are associated with cardiometabolic risk factors in women with previous gestational diabetes

B Akinci, A Celtik, S Tunali, S Genc, F Yuksel… - Archives of gynecology …, 2014 - Springer
Purpose Women with previous gestational diabetes mellitus (pGDM) are at high risk for type
2 diabetes and cardiovascular disorders. In this study, we aimed to compare plasma apelin …