Intratumoral fibrosis results from the deposition of a cross-linked collagen matrix by cancer-
associated fibroblasts (CAFs). This type of fibrosis has been shown to exert mechanical …

Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-
linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma …

Tumor-associated fibrosis is characterized by unchecked pro-fibrotic and pro-inflammatory
signaling. The components of fibrosis including significant numbers of cancer-associated …

Reciprocal interactions between tumor and stromal cells propel cancer progression and
metastasis. A complete understanding of the complex contributions of the tumor stroma to …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

Neoplastic cells recruit fibroblasts through various growth factors and cytokines. These
“cancer-associated fibroblasts”(CAF) actively interact with neoplastic cells and form a …

In the past century, gradual but sustained advances in our understanding of the molecular
mechanisms involved in the growth and invasive properties of cancer cells have led to better …

Accumulating evidence indicates that intratumoral heterogeneity contributes to the
development of resistance to anticancer therapeutics. Fibroblasts, which are components of …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

In malignant tumors, cancer cells adapt to grow within their host tissue. As a cancer
progresses, an accompanying host stromal response evolves within and around the nascent …