[HTML][HTML] A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response
Microglia are increasingly implicated in brain pathology, particularly neurodegenerative
disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease …
disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease …
[HTML][HTML] Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
Microglia, the brain-resident macrophages, exhibit highly dynamic functions in
neurodevelopment and neurodegeneration. Human microglia possess unique features as …
neurodevelopment and neurodegeneration. Human microglia possess unique features as …
[HTML][HTML] Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration
AM Speicher, H Wiendl, SG Meuth… - Molecular …, 2019 - Springer
Microglia play an essential role for central nervous system (CNS) development and
homeostasis and have been implicated in the onset, progression, and clearance of …
homeostasis and have been implicated in the onset, progression, and clearance of …
[HTML][HTML] Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia
SJ Washer, M Perez-Alcantara, Y Chen, J Steer… - Scientific Reports, 2022 - nature.com
There is increasing genetic evidence for the role of microglia in neurodegenerative
diseases, including Alzheimer's, Parkinson's, and motor neuron disease. Therefore, there is …
diseases, including Alzheimer's, Parkinson's, and motor neuron disease. Therefore, there is …
[HTML][HTML] Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology
Microglia play critical roles in brain development, homeostasis, and disease. Microglia in
animal models cannot accurately model human microglia due to notable transcriptomic and …
animal models cannot accurately model human microglia due to notable transcriptomic and …
[HTML][HTML] Microglia increase inflammatory responses in iPSC-derived human BrainSpheres
Human induced pluripotent stem cells (iPSCs), together with 21st century cell culture
methods, have the potential to better model human physiology with applications in …
methods, have the potential to better model human physiology with applications in …
[HTML][HTML] Development and validation of a simplified method to generate human microglia from pluripotent stem cells
Background Microglia, the principle immune cells of the brain, play important roles in
neuronal development, homeostatic function and neurodegenerative disease. Recent …
neuronal development, homeostatic function and neurodegenerative disease. Recent …
Efficient derivation of microglia-like cells from human pluripotent stem cells
Microglia, the only lifelong resident immune cells of the central nervous system (CNS), are
highly specialized macrophages that have been recognized to have a crucial role in …
highly specialized macrophages that have been recognized to have a crucial role in …
[HTML][HTML] Directed differentiation of human pluripotent stem cells to microglia
P Douvaras, B Sun, M Wang, I Kruglikov, G Lallos… - Stem cell reports, 2017 - cell.com
Microglia, the immune cells of the brain, are crucial to proper development and maintenance
of the CNS, and their involvement in numerous neurological disorders is increasingly being …
of the CNS, and their involvement in numerous neurological disorders is increasingly being …
[HTML][HTML] Human microglia maturation is underpinned by specific gene regulatory networks
Microglia phenotypes are highly regulated by the brain environment, but the transcriptional
networks that specify the maturation of human microglia are poorly understood. Here, we …
networks that specify the maturation of human microglia are poorly understood. Here, we …