Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis

RB Sartor - Nature clinical practice Gastroenterology & hepatology, 2006 - nature.com
Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory
conditions that are immunologically mediated. Although their exact etiologies remain …

New concepts in the pathophysiology of inflammatory bowel disease

G Bamias, MR Nyce, SA De La Rue… - Annals of internal …, 2005 - acpjournals.org
Ulcerative colitis and Crohn disease share certain similarities but are clearly distinct
diseases. Recent research challenges our conception of the pathophysiology of …

Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease

RB Sartor - Gastroenterology Clinics of North America, 1995 - Elsevier
Although the causes, events initiating and triggering inflammation, and the precise
immunoregulatory defects of IBD are still not known, investigations have provided a better …

Recent understanding of IBD pathogenesis: implications for future therapies

T Kucharzik, C Maaser, A Lügering… - Inflammatory bowel …, 2006 - academic.oup.com
The inflammatory bowel diseases (IBD) are comprised of two major phenotypes, Crohn's
disease (CD) and ulcerative colitis (UC). Research over the last couple of years has led to …

Location is important: differentiation between ileal and colonic Crohn's disease

R Atreya, B Siegmund - Nature Reviews Gastroenterology & …, 2021 - nature.com
Crohn's disease can affect any part of the gastrointestinal tract; however, current European
and national guidelines worldwide do not differentiate between small-intestinal and colonic …

Inflammatory bowel disease: past, present, and future

BE Sands - Journal of gastroenterology, 2007 - Springer
Crohn's disease and ulcerative colitis, collectively known as the inflammatory bowel
diseases (IBD), are largely diseases of the twentieth century, and are associated with the …

The immune response in inflammatory bowel disease

SJ Brown, L Mayer - Official journal of the American College of …, 2007 - journals.lww.com
Ulcerative colitis (UC) and Crohn's disease (CD), collectively referred to as inflammatory
bowel disease (IBD), present with differing histologic and cytokine profiles. While the precise …

Defects in mucosal immunity leading to Crohn's disease

GM Cobrin, MT Abreu - Immunological reviews, 2005 - Wiley Online Library
Crohn's disease (CD) is characterized by patchy transmural inflammation involving any part
of the intestinal tract. Animal models have provided a great deal of insight into the …

Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities

SB Hanauer - Inflammatory bowel diseases, 2006 - academic.oup.com
Ulcerative colitis (UC) and Crohn's disease (CD), the primary constituents of inflammatory
bowel disease (IBD), are precipitated by a complex interaction of environmental, genetic …

Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis

M Waterman, W Xu, JM Stempak… - Inflammatory bowel …, 2011 - academic.oup.com
Background A common genotypic basis for ulcerative colitis (UC) and Crohn's disease (CD)
is implied by overlapping clinical characteristics, epidemiological studies, and association of …