Relationship of plasma biomarkers to digital cognitive tests in Alzheimer's disease

S Toniolo, S Zhao, A Scholcz, B Amein… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION A major limitation in Alzheimer's disease (AD) research is the lack of the
ability to measure cognitive performance at scale—robustly, remotely, and frequently …

Performance and validation of a digital memory test across the Alzheimer's Disease continuum

S Toniolo, B Attaallah, MR Maio, YA Tabi, E Slavkova… - medRxiv, 2024 - medrxiv.org
Digital cognitive testing using online platforms has emerged as a potentially transformative
tool in clinical neuroscience. In theory, it could provide a powerful means of screening for …

Association of plasma biomarkers of Alzheimer's disease and related disorders with cognition and cognitive decline: The MYHAT population‐based study

Y Zhang, PCL Ferreira, E Jacobsen… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Plasma biomarkers of Alzheimer's disease and related dementias predict
global cognitive performance and decline over time; it remains unclear how they associate …

Amyloid-β, tau, and cognition in cognitively normal older individuals: examining the necessity to adjust for biomarker status in normative data

I Bos, SJB Vos, WJ Jansen… - Frontiers in aging …, 2018 - frontiersin.org
We investigated whether amyloid-β (Aβ) and tau affected cognition in cognitively normal
(CN) individuals, and whether norms for neuropsychological tests based on biomarker …

Current advances in digital cognitive assessment for preclinical Alzheimer's disease

F Öhman, J Hassenstab, D Berron… - Alzheimer's & …, 2021 - Wiley Online Library
There is a pressing need to capture and track subtle cognitive change at the preclinical
stage of Alzheimer's disease (AD) rapidly, cost‐effectively, and with high sensitivity …

Combining plasma phospho-tau and accessible measures to evaluate progression to Alzheimer's dementia in mild cognitive impairment patients

A Pichet Binette, S Palmqvist, D Bali, G Farrar… - Alzheimer's Research & …, 2022 - Springer
Background Up to now, there are no clinically available minimally invasive biomarkers to
accurately identify mild cognitive impairment (MCI) patients who are at greater risk to …

Using a Digital Neuro Signature to measure longitudinal individual-level change in Alzheimer's disease: the Altoida large cohort study

IB Meier, M Buegler, R Harms, A Seixas… - NPJ Digital …, 2021 - nature.com
Conventional neuropsychological assessments for Alzheimer's disease are burdensome
and inaccurate at detecting mild cognitive impairment and predicting Alzheimer's disease …

Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease

Z Xiao, X Wu, W Wu, J Yi, X Liang, S Ding… - Alzheimer's Research & …, 2021 - Springer
Background Plasma biomarkers showed a promising value in the disease diagnosis and
management of Alzheimer's disease (AD). However, profiles of the biomarkers and the …

Digital cognitive assessments as low-burden markers for predicting future cognitive decline and tau accumulation across the Alzheimer's spectrum

CR Vanderlip, CEL Stark - bioRxiv, 2024 - biorxiv.org
Digital cognitive assessments, particularly those that can be done at home, present as low
burden biomarkers for participants and patients alike, but their effectiveness in diagnosis of …

Remote and unsupervised digital memory assessments can reliably detect cognitive impairment in Alzheimer's disease

D Berron, E Olsson, F Andersson… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Remote unsupervised cognitive assessments have the potential to
complement and facilitate cognitive assessment in clinical and research settings. METHODS …