Diabetic nephropathy is a common complication of type I and type II diabetes, in which renal
glomeruli are destroyed, resulting in renal damage, proteinuria, and hypertension …

Diabetic kidney disease (DKD) accounts for a large proportion of end-stage renal diseases
that require renal replacement therapies including dialysis and transplantation. Therefore, it …

Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical
manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal …

Background. Apoptosis, which is involved in the process of mesangial cell and podocyte
loss in diabetic nephropathy, is known to be regulated by protein kinase B/Akt (Akt). A …

Cell death is thought to contribute to progressive renal cell depletion in diabetic
nephropathy. Unbiased gene expression profiling identified novel cell death molecules in …

Apoptosis contributes to the development of diabetic nephropathy, but the mechanism by
which high glucose induces apoptosis is not fully understood. Apoptosis of tubular epithelial …

The pathogenic mechanism of diabetic kidney disease (DKD) is involved in various
functions; however, its inadequate characterisation limits the availability of effective …

Aims/hypothesis Podocyte loss by apoptosis, in addition to favouring progression of
established diabetic nephropathy, has been recently indicated as an early phenomenon …

Diabetic nephropathy (DN) is characterized by sterile inflammation with continuous injury
and loss of renal inherent parenchyma cells. Podocyte is an essential early injury target in …

The occurrence and extent of apoptosis in the kidneys of patients with diabetic nephropathy
is largely unknown. We evaluated apoptosis in renal biopsies obtained from patients with …