Reactive oxygen species (ROS) are involved in several cell death processes, including
cerebral ischemic injury. We found that glutamate-induced ROS accumulation and the …

Primary neurons undergo insult-dependent programmed cell death. We examined
autophagy as a process contributing to cell death in cortical neurons after treatment with …

Reactive oxygen species (ROS) and antioxidant ingredients are a series of crucial signaling
molecules in oxidative stress response. Under some pathological conditions such as …

Exposure of mammalian cells to oxidant stress causes early (iron catalysed) lysosomal
rupture followed by apoptosis or necrosis. Enhanced intracellular production of reactive …

The endoplasmic reticulum (ER), which plays a role in apoptosis, is susceptible to oxidative
stress. Because superoxide is produced in the brain after ischemia/reperfusion, oxidative …

Ischemia is a major cause of brain damage, and patient management is complicated by the
paradoxical injury that results from reoxygenation. We have now explored the generation of …

Reactive oxygen species (ROS) are thought to be involved in many forms of programmed
cell death. The role of ROS in cell death caused by oxidative glutamate toxicity was studied …

While increasing evidence shows that proteasome inhibition triggers oxidative damage,
mitochondrial dysfunction and death in neuronal cells, the regulatory relationship among …

Background Reactive oxygen species (ROS) play an important role in aging and age-related
diseases such as Parkinson's disease and Alzheimer's disease. Much of the ROS …

Mitochondrial dysfunction and oxidative stress are implicated in many neurodegenerative
diseases. Mitochondria-targeted drugs that effectively decrease oxidative stress, protect …