After anaphase onset, animal cells build an actomyosin contractile ring that constricts the
plasma membrane to generate two daughter cells connected by a cytoplasmic bridge. The …

During animal cell division, the cleavage furrow is positioned by microtubules that signal to
the actin cortex at the cell midplane. We developed a cell-free system to recapitulate …

During cytokinesis, furrow ingression and plasma membrane fission irreversibly separate
daughter cells. How actomyosin ring assembly and contraction, vesicle fusion, and …

Cytokinesis is the process by which mitotic cells physically split in two following
chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then …

The mechanism of cytokinesis is an old problem in cell biology that has received fresh
attention recently with a large variety of powerful approaches and experimental systems …

Cell division—cytokinesis—involves large-scale rearrangements of the entire cell. Primarily
driven by cytoskeletal proteins, cytokinesis also depends on topological rearrangements of …

The mitotic spindle is a highly dynamic molecular machine composed of tubulin, motors, and
other molecules. It assembles around the chromosomes and distributes the duplicated …

The links between the cell cycle machinery and the cytoskeletal proteins controlling
cytokinesis are poorly understood. The small guanine nucleotide triphosphate (GTP) …

The molecular mechanisms that link cell-cycle controls to the mitotic apparatus are poorly
understood. A component of the Saccharomyces cerevisiae spindle, Ase1, was observed to …

Cytokinesis in many eukaryotes requires a contractile ring of actin and myosin that cleaves
the cell in two. Little is known about how actin filaments and other components assemble …