Simple Summary The Inhibitor of Apoptosis (IAP) family of proteins has emerged as a
potential pharmacological target in cancer. Abnormal expression of IAPs can lead to …

Inhibitor of apoptosis (IAP) proteins play a critical role in the control of survival and cell death
by regulating key signaling events such as caspase activation and NF-κB signaling …

Cell death by apoptosis plays a critical role in regulating the subtle balance between cell
death and proliferation to maintain tissue homeostasis. Accordingly, tipping the balance in …

The heterogeneous group of diseases collectively termed cancer results not just from
aberrant cellular proliferation but also from a lack of accompanying homeostatic cell death …

Chemo-or radioresistance markedly impairs the efficacy of cancer therapy and involves anti-
apoptotic signal transduction pathways that prevent cell death. In resistant cancer cells, both …

One of the hallmarks of cancer cells is their ability to evade cell death via apoptosis. The
inhibitor of apoptosis proteins (IAPs) are a family of proteins that act to promote cell survival …

Inhibitor of Apoptosis (IAP) proteins block programmed cell death and are expressed at high
levels in various human cancers, thus making them attractive targets for cancer drug …

Inhibitor of apoptosis (IAP) family comprises a group of endogenous proteins that function as
main regulators of caspase activity and cell death. They are considered the main culprits in …

Apoptosis has been accepted as a fundamental component in the pathogenesis of cancer,
in addition to other human diseases including neurodegeneration, coronary disease and …

Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular
process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of …