Since the discovery of the histamine H 3 receptor in 1983, tremendous advances in the
pharmacological aspects of H 3 receptor antagonists/inverse agonists have been …

Importance of the field: Histamine H3 receptor (H3R) antagonists/inverse agonists can be
therapeutically useful in the treatment of various CNS, metabolic syndrome and allergic …

The histamine H 3 receptor was discovered 15 years ago, and many potent and selective H
3 receptor agonists and antagonists have since been developed. Currently, much attention …

The neurotransmitter histamine exerts its action through four distinct histamine receptors.
The histamine H1 and H2 receptor are well established drug targets, whereas the histamine …

Introduction: Histamine H3 receptor (H3R) is involved in the central and peripheral
regulation of levels of histamine and other neurotransmitters (eg, acetylcholine …

Introduction: Several studies underlined the critical role of histamine H4 receptor (H4R) in
inflammation, thus H4 modulators have been suggested as promising drug candidates in …

Constitutive activity has been mainly recorded for numerous overexpressed and/or mutated
receptors. The histamine H 3 receptor (H 3 R) is a target of choice to study the physiological …

The identification of histamine H3 (H3R) and H4 (H4R) receptors some years ago revived
interest in histamine research and exposed attractive perspectives for the potential …

Publisher Summary Following the cloning of the histamine H 3 receptor cDNA, the level of
activity amongst both academic and pharmaceutical company laboratories has increased …

Introduction: The histamine H3 receptor (H3R) plays a pivotal role in a plethora of
therapeutic areas. Blocking the H3R with antagonists/inverse agonists has been postulated …